White Background with Triangle Pattern

Course Descriptions

Biomedical engineers use science, engineering, and mathematics to understand and solve medical problems. The biomedical engineering program at Rose‑Hulman produces engineers with the medical and biological expertise needed to solve health care problems during careers in technical and health-related industries, as well as in government or industrial laboratories.

Biomedical Engineering - Course Descriptions

BE 100 Problem Solving in the Biological Sciences & Engineering 3R-3L-4C S
Prerequisites: There are no prerequisites for this course.
Corequisites: There are no corequisites for this course.

This course introduces students to computational tools for solving problems in biology and biomedical engineering. The primary thrust of the course is structured programming in MatLab. In addition, we will explore data description, the proper presentation of data, effective use of spreadsheet tools in data analysis, structured programming, and an introduction to bioinformatics and Working Model.
BE 118 Design Thinking and Communication 1R-3L-2C F
Prerequisites: There are no prerequisites for this course.
Corequisites: There are no corequisites for this course.

Engineers must be able to communicate their design ideas to others. This course focuses on the improvement of communication skills, including written and oral presentation, sketching, and solid modeling. Student groups work on projects with the goal of recognizing and developing behaviors associated with consensus decision-making and cooperative teamwork. Students also learn the steps of the engineering design process and fundamental machining techniques.
BE 121 DC Circuits 1R-3L-2C F
Prerequisites: There are no prerequisites for this course.
Corequisites: There are no corequisites for this course.

This course introduces the fundamentals of DC circuit design and analysis. DC circuit analysis tools such as Kirchhoff’s laws, mesh and nodal analysis, superposition, and source transformations are introduced. In conjunction with BE128, students will complete projects that utilize microcontrollers and resistive sensors to interact with their environments.
BE 122 Systems Accounting and Modeling I 3R-0L-3C W
Prerequisites: MA 111 Calculus I
Corequisites: There are no corequisites for this course.

BE122 introduces the systems accounting and modeling approach to solving problems. Conservation of mass, linear and angular momentum, and energy will be introduced and reinforced with examples. Same as ENGD205.
BE 128 Design Thinking and Realization 2R-3L-3C W
Prerequisites: There are no prerequisites for this course.
Corequisites: BE 121 DC Circuits

This course explores elements of the engineering design process as a means of enhancing students’ abilities to define problems, develop and evaluate creative alternatives, and effectively present technical information.
BE 131 AC Circuits 1R-3L-2C S
Prerequisites: BE 121 DC Circuits
Corequisites: There are no corequisites for this course.

This course introduces the fundamentals of AC circuit design and analysis. Topics include RLC circuits, equivalent impedance, phasor domain analysis (nodal analysis, mesh current, source superposition, source transformation), and Thevenin and Norton theorems. The concept of linear systems and the use of electronic components (op-amps, capacitors, inductors) for biosignal processing applications will also be introduced. Students may not receive credit towards graduation for both BE131 and ES213.
BE 132 Systems Accounting and Modeling II 3R-0L-3C S
Prerequisites: BE 122 Systems Accounting and Modeling I
Corequisites: BE 131 AC Circuits

A common framework for engineering analysis is extended using the concepts of a system, accounting and conservation of extensive properties, constitutive relations, constraints, and modeling assumptions. Stress, strain, and deformation under axial loading are defined. Equilibrium is defined. Conservation equations for mass, charge, momentum and energy are developed. Applications are developed from multiple engineering disciplines. Students may not receive credit towards graduation for both BE132 and ES201. Same as ENGD215.
BE 138 Design Thinking and Human-Centered Products 2R-3L-3C S
Prerequisites: There are no prerequisites for this course.
Corequisites: BE 131 AC Circuits

This project-based design course focuses on ensuring that products meet the needs of their users. The course incorporates observational methods, brainstorming, prototyping, user testing, business models, and the social, marketing, and engineering constraints that impinge upon products.
BE 201 Biomedical Instrumentation & Measurements 3R-3L-4C W,S
Prerequisites: BE 100 Problem Solving in the Biological Sciences & Engineering , and ES 203 Electrical Systems
Corequisites: There are no corequisites for this course.

Discussion of measurement principles for biomedical engineering. Topics include op-amp circuit analysis, frequency analysis, fundamentals of digital gates and flip-flops, different types of biomedical sensors (temperature, force, pressure, velocity, etc), and basics of microcontrollers and embedded system.
BE 202 Circuits, Sensors, and Measurements 3R-3L-4C F
Prerequisites: ENGD 120 Integrating Electrical, Software, and Societal Systems , MA 103 Applied Multivariate Calculus or MA 113 Calculus III permission of instructor.
Corequisites: There are no corequisites for this course.

Discussion of measurement principles and signal conditioning circuits for biomedical engineering. This course reinforces topics such as DC and AC circuit analysis techniques and explores topics such as op-amp circuit and frequency analysis in the context of biomedical signal conditioning. Fundamentals of digital logics and flip-flops will also be introduced. Lastly, the working principles of different types of biomedical sensors (surface potential, temperature, force, pressure, velocity), and the topic of uncertainty analysis will also be covered.
BE 204 Mechanics of Materials 4R-0L-4C F
Prerequisites: ENGD 215 Systems Accounting and Modeling II or EM 121 Statics & Mechanics of Materials I
Corequisites: There are no corequisites for this course.

Description: Strength and elastic deflection of engineering materials due to loads applied in torsion, in bending, and in shear. Shear diagrams, bending moment diagrams, and area moments of inertia. Combined stresses and principal stresses. Applications to design of beams and shafts.
BE 211 Circuits, Sensors, and Measurements 2R-3L-3C F
Prerequisites: BE 131 AC Circuits , and MA 112 Calculus II
Corequisites: There are no corequisites for this course.

This course introduces the concepts of biomedical signal measurement and conditioning. Topics include amplifiers, filters and A/D converters, digital logic, biomedical sensors and uncertainty analysis. Matlab is used in the context of biosignal acquisition and visualization.
BE 212 Biomedical Fluid Mechanics 3R-0L-3C W
Prerequisites: ES 201 Conservation & Accounting Principles or ENGD 215 Systems Accounting and Modeling II , and BIO 120 Comparative Anatomy & Physiology
Corequisites: There are no corequisites for this course.

Fluid mechanics as applied to physiological systems. Includes discussion of cardiovascular physiology, Poiseuille flow, pulsatile flow, fluid transport in the microcirculation, blood flow and pressure measurement in the clinical environment, dimensional analysis and modeling.
BE 218 Design Methodologies 2R-3L-3C F
Prerequisites: BE 138 Design Thinking and Human-Centered Products
Corequisites: There are no corequisites for this course.

Introduction to the philosophy and goals of various design and research processes. Hands-on projects will serve as vehicles for design thinking, visualization, and methodology.
BE 222 Mechanics of Materials 4R-0L-4C W
Prerequisites: BE 132 Systems Accounting and Modeling II
Corequisites: There are no corequisites for this course.

Description: Strength and elastic deflection of engineering materials due to loads applied in torsion, in bending, and in shear. Shear diagrams, bending moment diagrams, and area moments of inertia. Combined stresses and principal stresses. Applications to design of beams and shafts.
BE 228 Design Leadership & Teamwork 1R-3L-2C W
Prerequisites: BE 218 Design Methodologies
Corequisites: There are no corequisites for this course.

This project-based course will help students develop skills in decision-making, leadership, and management of complex design projects.
BE 232 Biomechanics 3R-0L-3C W
Prerequisites: BE 211 Circuits, Sensors, and Measurements , and either BE 222 Mechanics of Materials or EM 204 Statics & Mechanics of Materials II
Corequisites: There are no corequisites for this course.

This course introduces students to the various interdisciplinary fields in biomechanics - such as orthopaedic biomechanics, biofluid mechanics, soft tissue mechanics, and the biomechanics of human movement. Specific topics include: statics/dynamics of the human body, kinematics during activity; the analysis of forces and stresses/strains in biological structures under loading; constitutive models for biological materials (e.g. bone, cartilage, tendon/ligament); and the relationship between structure and function in tissues and organs. Non-majors interested in taking this course should see the instructor.
BE 233 Biomaterials 3R-0L-3C W
Prerequisites: There are no prerequisites for this course.
Corequisites: There are no corequisites for this course.

Structure-property relationships for metallic, polymeric, and ceramic biomaterials. Study of the interactions of these materials with the body and factors affecting the selection and design of materials for medical implants and devices.
BE 238 Regulatory Affairs & Product Design 3R-3L-4C S
Prerequisites: There are no prerequisites for this course.
Corequisites: There are no corequisites for this course.

Students will build a fundamental understanding of how the FDA regulates medical devices in the United States, with an emphasis on pathways to market. Project is in conjunction with BE232 and BE233. Includes the submission and review process of a student’s AIMS for BE majors (peer, career services, faculty, advisory board approval).
BE 310 Analysis of Physiological Systems I 3R-3L-4C W
Prerequisites: BIO 120 Comparative Anatomy & Physiology , and BIO 205 Cellular Physiology
Corequisites: There are no corequisites for this course.

An analysis of neural, muscular, and endocrine physiology from a quantitative, systems-based approach.
BE 314 Musculoskeletal Systems Physiology with Applications 4R-0L-4C F
Prerequisites: BIO 110 Cell Structure and Function , and BE 232 Biomechanics , and BE 233 Biomaterials
Corequisites: BE 315 Biomedical Engineering Lab I

An analysis of muscle, bone, and soft tissue physiology/mechanics from a quantitative, system-based approach with an emphasis on clinical applications.
BE 315 Biomedical Engineering Lab I 1R-3L-2C F
Prerequisites: BE 232 Biomechanics , and BE 233 Biomaterials
Corequisites: BE 314 Musculoskeletal Systems Physiology with Applications

This course emphasizes the fundamental concepts in biomechanics and biomaterials with an emphasis on musculoskeletal applications. Hands-on laboratory projects will be assigned which will require the student to use standard testing equipment and basic instrumentation to execute effective test methods. Written communication of experimental results is emphasized. Non-majors interested in taking this course should see the instructor.
BE 317 Design for Biomedical Manufacturing 1R-0L-1C W
Prerequisites: EM 104 Graphical Communications
Corequisites: There are no corequisites for this course.

This BE course is to be taken concurrently with ME317, Design for Manufacturing. This course presents manufacturing methods associated with biomedical products and situates Design for Manufacturing within the larger context of cradle to cradle design processes. Current biomedical industry processes and issues are emphasized. Taking ME317 and BE317 simultaneously, and passing both courses, will fulfill the requirement for a 4-credit BE biomechanics or biomaterials concentration elective.
BE 318 Medical Device Research & Design 2R-3L-3C F
Prerequisites: BE 238 Regulatory Affairs & Product Design
Corequisites: There are no corequisites for this course.

In this course students collaborate with clinicians, industry partners, and/or community partners to identify unmet clinical or research needs. Based on voice of the customer feedback, stakeholder analysis, market analysis, and evaluation of the regulatory and technical landscape, teams will refine observed needs and present them to reviewers. Projects identified to have a significant impact, a committed team, and a viable market can be continued in BE328.
BE 320 Analysis of Physiological Systems II 3R-3L-4C S
Prerequisites: BE 310 Analysis of Physiological Systems I
Corequisites: There are no corequisites for this course.

An analysis of cardiovascular, pulmonary, and renal physiology from a quantitative, systems-based approach.
BE 321 Biosignal Processing 3R-3L-4C W
Prerequisites: BE 211 Circuits, Sensors, and Measurements , and MA 211 Differential Equations
Corequisites: BE 324 Neural and Endocrine Systems Physiology with Applications

This course introduces the fundamentals of biomedical signal processing strategies. Topics include data acquisition, A/D and D/A conversion, FIR and IIR digital filter design, time-frequency analysis, and I/O interfaces. Multichannel data processing and high dimensional data analysis techniques are also introduced. Laboratories provide practical experience on the analysis of electrophysiological data, with special emphasis on neurological signals. Students may not receive credit towards graduation for both BE321 and ECE380 or ECE300.
BE 324 Neural and Endocrine Systems Physiology with Applications 3R-3L-4C W
Prerequisites: BIO 110 Cell Structure and Function , and BE 211 Circuits, Sensors, and Measurements , and BE 314 Musculoskeletal Systems Physiology with Applications
Corequisites: There are no corequisites for this course.

An analysis of neural and endocrine physiology from a quantitative, systems-based approach.
BE 328 Capstone Design I: Designing Products for the Real World 3R-3L-4C W
Prerequisites: BE 118 Design Thinking and Communication , and BE 128 Design Thinking and Realization , and BE 211 Circuits, Sensors, and Measurements , and BE 228 Design Leadership & Teamwork , and BE 232 Biomechanics , and BE 233 Biomaterials , and BE 318 Medical Device Research & Design
Corequisites: There are no corequisites for this course.

This course begins the capstone design sequence in biomedical engineering. Student teams develop design solutions from a set of client-specified needs, establish specifications, plan the project, schedule and efficiently use resources, examine the ethics and safety in engineering design, and work within explicit (or implicit) constraints, such as social, economic, manufacturing, etc. The course culminates with the presentation of the preliminary proposal for the capstone design project in biomedical engineering.
BE 331 Biomechanics 3R-0L-3C W
Prerequisites: ENGD 215 Systems Accounting and Modeling II , and BE 202 Circuits, Sensors, and Measurements , and either EM 204 Statics & Mechanics of Materials II or BE 204 Mechanics of Materials or consent of instructor
Corequisites: BE 351 Biomedical Engineering Lab or BE 352 Biomechanics Lab ,and BE 361 Biomaterials

This course introduces students to the various interdisciplinary fields in biomechanics - such as orthopaedic biomechanics, biofluid mechanics, soft tissue mechanics, and the biomechanics of human movement. Specific topics include: statics/dynamics of the human body, kinematics during activity; the analysis of forces and stresses/strains in biological structures under loading; constitutive models for biological materials (e.g. bone, cartilage, tendon/ligament); and the relationship between structure and function in tissues and organs. Non-majors interested in taking this course should see the instructor.
BE 334 Cardiovascular, Respiratory, and Renal Systems Physiology with Applications 3R-3L-4C S
Prerequisites: BIO 110 Cell Structure and Function , and BE 314 Musculoskeletal Systems Physiology with Applications , and BE 315 Biomedical Engineering Lab I
Corequisites: There are no corequisites for this course.

An analysis of cardiovascular, pulmonary, and renal physiology from a quantitative, systems-based approach with an emphasis on biomedical applications.
BE 335 Biomedical Engineering Lab II 1R-3L-2C S
Prerequisites: BE 315 Biomedical Engineering Lab I
Corequisites: There are no corequisites for this course.

This course emphasizes experimental design and execution in biomechanics, biomaterials, and fluid mechanics with an emphasis on cardiovascular applications. Laboratory experiences will require the student to use standard testing equipment and basic instrumentation to execute effective test methods. Written communication as well as experimental design and execution is emphasized. Non-majors interested in taking this course should see the instructor.
BE 338 Capstone Design II: Product Design & Prototyping 3R-3L-4C S
Prerequisites: BE 328 Capstone Design I: Designing Products for the Real World
Corequisites: There are no corequisites for this course.

This course is a continuation of BE328. The student teams develop prototype solutions through implementation of the design plan from the previous course. This includes development of a test plan, modifications to the design project as needed, risk assessment, and evaluation of design performance relative to initial specifications. This course culminates in the submission of a functional prototype and updated design history files.
BE 340 Biomedical Signal Processing 3R-3L-4C F
Prerequisites: BE 201 Biomedical Instrumentation & Measurements , ES 203 Electrical Systems
Corequisites: There are no corequisites for this course.

This course introduces the fundamental of biomedical signal processing strategies. Topics include data acquisition, A/D and D/A conversion, digital filter design, time-frequency analysis, and I/O interfaces. Multichannel data processing and high dimensional data analysis techniques are also covered. Lectures will be accompanied by data analysis assignments and projects using MATLAB, LabVIEW, and microcontrollers.
BE 350 Biocontrol Systems 4R-0L-4C
Prerequisites: ES 205 Analysis & Design of Engineering Systems
Corequisites: There are no corequisites for this course.

Biomedical engineers use science, engineering, and mathematics to understand and solve medical problems. The biomedical engineering program at Rose-Hulman produces engineers with the medical and biological expertise needed to solve health care problems during careers in technical and health-related industries, as well as in government or industrial laboratories.
BE 351 Biomedical Engineering Lab 1R-3L-2C
Prerequisites: There are no prerequisites for this course.
Corequisites: BE 331 Biomechanics ,and BE 361 Biomaterials

This course emphasizes the fundamental concepts in biomechanics and biomaterials through hands-on experience with standard testing equipment. Laboratory projects will be assigned which will require the students to use basic instrumentation to determine and execute effective test methods. Non-majors interested in taking this course should see the instructor
BE 352 Biomechanics Lab 0R-3L-1C
Prerequisites: ES 201 Conservation & Accounting Principles , EM 204 Statics & Mechanics of Materials II , and BE 201 Biomedical Instrumentation & Measurements or consent of instructor
Corequisites: BE 331 Biomechanics

This course emphasizes the fundamental concepts in biomechanics through hands-on experience with standard testing equipment. Laboratory projects will be assigned which will require the students to use basic instrumentation to determine and execute effective test methods.
BE 353 Biomaterials Lab 0R-3L-1C
Prerequisites: ES 201 Conservation & Accounting Principles , EM 204 Statics & Mechanics of Materials II , and BE 201 Biomedical Instrumentation & Measurements
Corequisites: BE 361 Biomaterials

This course emphasizes the fundamental concepts in biomaterials through hands-on experience with standard testing equipment. Laboratory projects will be assigned which will require the students to use basic instrumentation to determine and execute effective test methods.
BE 361 Biomaterials 3R-0L-3C W
Prerequisites: There are no prerequisites for this course.
Corequisites: There are no corequisites for this course.

Structure-property relationships for metallic, polymeric, and ceramic biomaterials. Study of the interactions of these materials with the body and factors affecting the selection and design of materials for medical implants and devices.
BE 385 Quality Methods 4R-0L-4C S
Prerequisites: MA 223 Engineering Statistics I or MA 382 Introduction to Statistics with Probability
Corequisites: There are no corequisites for this course.

Introduction to various aspects of statistical quality control and statistical process control to include the following topics: importance of variance reduction and probability concepts influencing product quality and reliability; development and application of control charts (Pcharts, NP-charts, C-charts, U-charts, individual’s charts, moving range charts, X-bar and R as well as X-bar and S charts); process capability indices (their use and misuse); introduction to acceptance sampling. Other topics to be included as time allows: 6 sigma thinking, gauge reproducibility and repeatability, and total quality management with the philosophies of Deming, Juran, and Crosby. Review of fundamental prerequisite statistics will be included as necessary. Same as MA 385
BE 390 Principles of Biomedical Engineering Design 1R-3L-2C S
Prerequisites: BE 201 Biomedical Instrumentation & Measurements or BE 202 Circuits, Sensors, and Measurements
Corequisites: EM 204 Statics & Mechanics of Materials II or BE 204 Mechanics of Materials

In this course, junior BE majors are introduced to the engineering design methodology as utilized in biomedical engineering. Students will learn engineering design through completion of a team design project with realistic constraints. This course serves as the entry point for the four-quarter sequence in which students undertake and complete their capstone design project.
BE 400 Consulting Engineering Seminar 2R-0L-2C S
Prerequisites: Junior class standing
Corequisites: There are no corequisites for this course.

Discusses problems in the field of consulting engineering; includes seminars presented by practicing consulting engineers and a suitable project to practice consulting skills. Cross-listed with CE420, ME420, CHE420, ECE466.
BE 410 Biomedical Engineering Design I 3R-3L-4C F
Prerequisites: BE 390 Principles of Biomedical Engineering Design
Corequisites: There are no corequisites for this course.

This course begins the year-long capstone design project and continues to investigate the process of design in biomedical engineering by having student teams initiate the design process for a relevant problem in biomedical engineering. This includes developing the design problem from a set of client needs, establishing specifications, planning the project, scheduling, efficient use of resources, examining ethics and safety in engineering design, and working within explicit (or implicit) constraints such as social, fiscal, manufacturing, etc. The course culminates with the presentation of the preliminary proposal for the capstone design project in biomedical engineering.
BE 418 Capstone Design III: Product Verification and Validation 3R-3L-4C F
Prerequisites: BE 338 Capstone Design II: Product Design & Prototyping
Corequisites: There are no corequisites for this course.

This course is a continuation of BE338. The student teams iterate on the initial functional prototype based on client feedback, complete testing of the prototype solutions, and transfer the project results to their client. The course culminates with the submission of a critical design document.
BE 420 Biomedical Engineering Design II 2R-6L-4C W
Prerequisites: BE 410 Biomedical Engineering Design I
Corequisites: There are no corequisites for this course.

This course is a continuation of BE410 by having student teams implement their design plan. This will include development of a test plan, modifications to the design project as needed, and assessment of design performance relative to initial specifications. This course culminates in the submission of the final design document.
BE 428 Capstone Design IV: Integrated Product Design & Practice 1R-3L-2C W
Prerequisites: BE 418 Capstone Design III: Product Verification and Validation
Corequisites: There are no corequisites for this course.

This course is a continuation of BE418. Student teams finalize design prototypes, reflect on future product development opportunities, and complete documentation requirements to established standards and specifications. Students participate in a mentorship program with students enrolled in BE328 and begin development of a professional design portfolio.
BE 430 Biomedical Engineering Design III 1R-3L-2C S
Prerequisites: BE 420 Biomedical Engineering Design II
Corequisites: There are no corequisites for this course.

This course is a continuation of BE420 and introduces students to the skills necessary for professional practice in biomedical engineering including project management, review of critical design decisions, mentoring design teams, etc. The biomedical engineering design sequence culminates in the formal oral presentation of the capstone design report.
BE 435 Biomedical Optics 3.5R-1.5L-4C
Prerequisites: PH 113 Physics III , and MA 223 Engineering Statistics I or Senior/Graduate standing or consent of instructor
Corequisites: There are no corequisites for this course.

Optical techniques for biomedical applications and health care; laser fundamentals, laser interaction with biological cells, organelles and nanostructures; laser diagnostics and therapy, laser surgery; microscopes; optics-based clinical applications; imaging and spectroscopy, biophotonics laboratories. For graduate credit, students must do additional project work on a topic selected by the instructor. Cross-listed with OE 435.
BE 438 Engineering Portfolio Development 1R-3L-2C S
Prerequisites: BE 428 Capstone Design IV: Integrated Product Design & Practice
Corequisites: There are no corequisites for this course.

Students complete a portfolio showcasing their engineering design work to further a specific professional goal. Examples of professional goals include developing a career plan, pursuing patent opportunities, or establishing a business plan for a start-up. Students participate in a mentorship program with students enrolled in BE338.
BE 482 Biostatistics 4R-0L-4C
Prerequisites: MA 223 Engineering Statistics I or MA 382 Introduction to Statistics with Probability and consent of instructor (cross listed with MA 482)
Corequisites: There are no corequisites for this course.

Hypothesis testing and confidence intervals for two means, two proportions, and two variances. Introduction to analysis of variance to include one factor and two factors (with interaction) designs. Presentation of simple linear and multiple linear regression modeling; development of analysis of contingency table to include logistic regression. Presentation of Log odds ratio as well as several non-parametric techniques of hypothesis testing and construction of non-parametric confidence intervals and correlation coefficients. Review of fundamental prerequisite statistics will be included as necessary.
BE 491 Special Topics in Biomedical Engineering XR-0L-XC
Prerequisites: Arranged prerequisite consent of instructor
Corequisites: There are no corequisites for this course.

Covers upper-level, undergraduate material of mutual interest to student and instructor which cannot be acquired in any other listed undergraduate BE course.
BE 492 Directed Study in Biomedical Engineering XR-XL-XC
Prerequisites: Arranged prerequisite consent of instructor
Corequisites: There are no corequisites for this course.

Covers biomedical engineering material of mutual interest to the student and instructor which cannot be experienced in any other listed BE course. A student may take between 1-4 credits in any given term.
BE 499 Thesis Research 0R-6L-2C F,W,S
Prerequisites: Junior or senior standing
Corequisites: There are no corequisites for this course.

Culmination of biomedical engineering thesis research in which a student writes and submits the senior thesis, following departmentally established guidelines, and gives an oral research presentation to at least three departmental faculty members, including the student's adviser. BE499 may not be used as a biomedical engineering area elective.
BE 510 Biomedical Signal & Image Processing 3R-3L-4C W
Prerequisites: BE 201 Biomedical Instrumentation & Measurements JR, SR or Graduate standing or consent of instructor
Corequisites: There are no corequisites for this course.

Provides a comprehensive survey of signal and image processing tools for biomedical applications. Major biological signals (e.g., ECG), biomedical imaging techniques (e.g., MRI), their origin and importance, and the commonly used processing techniques with an emphasis on physiology and diagnostic applications will be discussed.
BE 511 Analysis of Physiological Systems I 3R-3L-4C W
Prerequisites: Junior, Senior, Graduate standing or consent of instructor
Corequisites: There are no corequisites for this course.

An analysis of neural, muscular, endocrine, and digestive physiology from a quantitative, systems-based approach. Both recent and classical journal articles will be discussed in class. Students enrolled in BE511 must complete a project not covered in BE310. Students may not receive credit for both BE511 and BE310.
BE 512 Analysis of Physiological Systems II 3R-3L-4C S
Prerequisites: Graduate standing or consent of instructor
Corequisites: There are no corequisites for this course.

An analysis of cardiovascular, pulmonary, and renal physiology from a quantitative, systems-based approach. Both recent and classical journal articles will be discussed in class. (Note: BE511 is not a prerequisite for BE512). Students enrolled in BE512 must complete a project not covered in BE320. Students may not receive credit for both BE512 and BE320.
BE 516 Introduction to MEMS: Fabrication & Applications 3R-3L-4C S
Prerequisites: JR or SR standing
Corequisites: There are no corequisites for this course.

Properties of silicon wafers, wafer-level processes, surface and bulk micromachining, thin-film deposition, dry and wet etching, photolithography, process integration, simple actuators. Introduction to microfluidic systems. MEMS application: capacitive accelerometer, cantilever and pressure sensor. Students enrolled in BE516 must do project work on a topic selected by the instructor. Cross-listed with CHE 505, ECE 516, EP 510, and ME 516.
BE 520 Introduction to Brain Machine Interfaces 3R-3L-4C S
Prerequisites: BE 340 Biomedical Signal Processing or ECE 480 Introduction to Image Processing
Corequisites: There are no corequisites for this course.

This course is an introduction to the basics of motor cortical functions related to voluntary and imagery movements, evoked response potentials, invasive vs. noninvasive electrode design considerations, quantitative EEG analysis techniques used in clinical settings, and the applications of brain-machine interfaces/brain-computer interfaces in the restoration of mobility, communication and motor function.
BE 531 Biomechanics II 3R-3L-4C
Prerequisites: BE 331 Biomechanics or consent of instructor
Corequisites: There are no corequisites for this course.

Covers statics, dynamics and deformable body mechanics of biological systems. Topics include joint anatomy, muscle physiology, biomechanics of distance running, physiological response to acceleration, mechanics of bone, joint biomechanics and selected topics from current literature. The course includes a lab covering the use of a motion analysis system and force platforms.
BE 534 Soft Tissue Mechanics 3 R-3L-4C
Prerequisites: EM 203 Mechanics of Materials , and EM 204 Statics & Mechanics of Materials II or BE 331 Biomechanics or consent of instructor
Corequisites: There are no corequisites for this course.

This course provides an introduction to the various approaches used in modelling soft tissues, with particular attention paid to those of the musculoskeletal system (e.g. ligament, tendon, cartilage). Particular emphasis will be placed on the theoretical and experimental consequences of the large deformation behavior of these tissues. This course will serve as a Biomechanics track elective.
BE 535 Biomedical Optics 4R-0L-4C W
Prerequisites: PH 113 Physics III , MA 212 Matrix Algebra & Systems of Differential Equations and SR standing or GR standing
Corequisites: There are no corequisites for this course.

Optical techniques for biomedical applications and health care; imaging modalities; laser fundamentals, laser interaction with biological cells, organelles and nanostructures; laser diagnostics and therapy, laser surgery; microscopes; optics-based clinical applications; imaging and spectroscopy; biophotonics. Students must do additional project work on a topic selected by the instructor. Students may not receive credit for both OE 435 and OE 535. Cross-listed with OE 535.
BE 539 Multiscale Biomechanics 3R-3L-4C
Prerequisites: EM 203 Mechanics of Materials or EM 204 Statics & Mechanics of Materials II , and BE 331 Biomechanics or consent of instructor
Corequisites: There are no corequisites for this course.

This course provides a comprehensive exploration/overview of the multiple approaches available for the analysis of multiscale media, beginning from classical approaches in composite theory and moving on to various structure-function and homogenization models. Specific attention will be placed on the application of these ideas to heterogeneous and finite deformation biological tissues (e.g. bone, cartilage, ligament, vessels, etc.). This course will serve as a Biomechanics track elective.
BE 541 Medical Imaging Systems 4R-0L-4C
Prerequisites: BE 340 Biomedical Signal Processing * *Graduate standing; or with a grade of B or better; or consent of instructor.
Corequisites: There are no corequisites for this course.

Engineering principles of major imaging techniques/modalities for biomedical applications and health care including diagnostic x-ray, computed tomography, nuclear techniques, ultrasound, and magnetic resonance imaging. Topics include general characteristics of medical images; physical principles, signal processing to generate an image, and instrumentation of imaging modalities. Clinical applications of these technologies are also discussed. Same as ECE584.
BE 543 Neuroprosthetics 3R-3L-4C
Prerequisites: BE 310 Analysis of Physiological Systems I , and BE 201 Biomedical Instrumentation & Measurements
Corequisites: There are no corequisites for this course.

This course takes a detailed look at the state of the art in Neuroprosthetics design and applications. Topics include electrode design, sensory prosthetics, functional electrical stimulation, deep brain stimulation and other contemporary research topics.
BE 545 Orthopaedic Biomechanics 4R-0L-4C
Prerequisites: EM 203 Mechanics of Materials or EM 204 Statics & Mechanics of Materials II , and BE 331 Biomechanics or consent of instructor
Corequisites: There are no corequisites for this course.

This course covers current topics in orthopaedic biomechanics including the application of solid mechanics principles to musculoskeletal activities, orthopaedic implants, and fracture fixation devices. Topics include joint loading; composition and mechanical behavior of orthopaedic tissues; design/analysis of artificial joints and fracture fixation prostheses; osteoporosis and osteoarthritis; and finite element modeling.
BE 550 Research Methods in Biomechanics 3R-3L-4C W
Prerequisites: BE 331 Biomechanics or consent of instructor
Corequisites: There are no corequisites for this course.

Focuses on the wide range of research methods used in the field of biomechanics. Current literature will be reviewed to analyze the advantages and disadvantages of various research methodologies. Topics will vary based on student interests and background, but may include topics such as motion/force analysis, soft tissue and bone mechanics, joint biomechanics, analysis of joint replacements, and fracture fixation. Laboratory activities will reinforce the lecture topics and students will have the opportunity to investigate a biomechanics research topic in their area of interest.
BE 555 Electrophysiology 3R-3L-4C
Prerequisites: Junior, Senior, Graduate standing or consent of instructor
Corequisites: There are no corequisites for this course.

Introduces students to concepts of electrical activity in cells and organs of the body. Topics include: origin of membrane potential, membrane channels, synaptic signaling, recording techniques, gross electrical potentials (e.g. electrocardiogram, electroencephalogram, electromyogram, electroretinogram). Emphasis will be placed on how these signals are used to probe physiological function in the clinic and in the research laboratory.
BE 560 Tissue-Biomaterial Interactions 4R-0L-4C
Prerequisites: BE 361 Biomaterials or consent of instructor
Corequisites: There are no corequisites for this course.

Addresses interactions between living cells/tissues and implant biomaterials, stressing the importance of molecular- and cellular-level phenomena in initiating and propagating clinically relevant tissue- and systemic- level results.
BE 565 Experimental Methods in Tissue-Biomaterial Interactions 3R-3L-4C S
Prerequisites: BE 361 Biomaterials or consent of instructor
Corequisites: There are no corequisites for this course.

This course focuses on teaching students experimental methods used for investigations of tissue-biomaterial interactions. Topics include bioethics issues associated with experiments on cells, tissues, animals, and people; biosafety issues associated with cells/tissues from animals and humans; the design, critique, and statistical analysis of experiments. Students conduct hands-on investigations of cell-biomaterial interactions which require the use of common laboratory equipment, aseptic technique, mammalian cell culture, and current molecular methods to investigate cell viability, structure, and function.
BE 570 Introduction to Tissue Engineering 4R-0L-4C
Prerequisites: Junior, Senior, or Graduate standing or permission of instructor
Corequisites: There are no corequisites for this course.

This course provides a broad overview of the latest developments in the field of tissue engineering. Normal structure and function of tissues and organs such as bone, cartilage, nerve, skin, and liver are discussed. Methods of engineering these tissues, or encouraging healing or regeneration that would not otherwise occur, is the focus of the course. The course takes the format of a graduate seminar, with students taking an active role in presenting material to the class and leading discussions.
BE 590 Thesis Research Credits as assigned F,W,S
Prerequisites: There are no prerequisites for this course.
Corequisites: There are no corequisites for this course.

Credits as assigned: however, not more than 12 credits will be applied toward the requirements of an M.S. degree.
BE 597 Selected Topics Credits as assigned F,W,S
Prerequisites: There are no prerequisites for this course.
Corequisites: There are no corequisites for this course.

Selected Topics for Graduate Students Credits as assigned. Maximum 4 credits per term.
BE 621 Microbiology and Immunology 6C
Prerequisites: There are no prerequisites for this course.
Corequisites: There are no corequisites for this course.

Lectures, conferences and laboratories covering the immune response as a chemical and cellular Surveillance system; the consequences of activation of the immune system; and viruses, bacteria, fungi and protozoan and metazoan parasites as organisms and as agents of human disease. *Course is offered at the Terre Haute Center for Medical Education and may be taken for Rose-Hulman credit. To enroll in this course RHIT students need permission from the Chairman of the Department of Applied Biology and Biomedical Engineering.
BE 623 Gross Anatomy 8C
Prerequisites: There are no prerequisites for this course.
Corequisites: There are no corequisites for this course.

An intensive study of the gross structure of the human body accomplished through maximum student participation in the dissection of the human cadaver. Lectures are interpretive and correlative. Audiovisual supplementation is provided. *Course is offered at the Terre Haute Center for Medical Education and may be taken for Rose-Hulman credit. To enroll in this course RHIT students need permission from the Chairman of the Department of Applied Biology and Biomedical Engineering.
BE 624 Biochemistry 6C
Prerequisites: There are no prerequisites for this course.
Corequisites: There are no corequisites for this course.

The chemistry and reactions of constituents of living matter, including the carbohydrates, lipids, proteins, nucleic acids, vitamins, coenzymes and minerals; the chemistry and regulation of the reactions and processes of whole organisms; endocrinology; enzymology; nutrition; intermediary metabolism; and biochemical mechanisms in selected disease states. *Course is offered at the Terre Haute Center for Medical Education and may be taken for Rose-Hulman credit. To enroll in this course RHIT students need permission from the Chairman of the Department of Applied Biology and Biomedical Engineering
BE 625 Physiology 8c
Prerequisites: There are no prerequisites for this course.
Corequisites: There are no corequisites for this course.

The course in human physiology covers, in lectures and laboratories, such topics as circulation, respiration, digestion, endocrinology, heat metabolism, renal physiology, muscle physiology, and neurophysiology. *Course is offered at the Terre Haute Center for Medical Education and may be taken for Rose-Hulman credit. To enroll in this course RHIT students need permission from the Chairman of the Department of Applied Biology and Biomedical Engineering.
BE CPT Curricular Practical Training 1R-0L-1C
Prerequisites: Consent of Department Head
Corequisites: There are no corequisites for this course.

Any international student with an F-1 Visa employed by any company in the form of an internship, co-op, or practicum must enroll in a CPT course. The CPT experience is to be complimentary training to the student's curriculum and should contribute substantially to his/her learning experience. Students must have an offer of employment from a company prior to registering for this course. The CPT must be approved by the Department Head, Director of International Student Services, and the student's adviser. Students are required to submit a report at the conclusion of the employment to his/her instructor to receive a grade for the CPT experience.
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