Graduate level course offerings: Applied Biology &
Biomedical Engineering
Applied Biology
AB 401 Biology Colloquium 2R-0L-2C S
Prerequisite: Senior standing
Oral presentations and discussion of selected timely topics.
AB 410 Infection and
Immunity 4R-0L-4C
Arranged Prerequisite: AB 110 or consent of
instructor
Discussion of various pathogens, how they cause disease, and how
they elicit the innate and adaptive immune responses employed to
combat them. Cellular and molecular mechanisms of immunity are
addressed, as is the epidemiology of various human diseases.
AB 411 Genetic Engineering 4R-0L-4C
Arranged Prerequisite: AB 210 or consent of
instructor
Discusses the basics of molecular biology and the genetic and
molecular techniques used to engineer prokaryotic and eukaryotic
cells, plants, and animals for the production of useful traits or
compounds. The application of DNA technology to the diagnosis and
treatment of disease is also addressed.
AB 421 Applied Microbiology 4R-0L-4C
Arranged Prerequisite: AB 110 or consent of
instructor
Discusses the fundamental biology of microprobes and the processes
underlying their use in the production of chemicals, therapeutics
and foods. The basics of microbial ecology and the environmental
applications of microbial biotechnology are also discussed.
AB 431 Genomics and Proteomics 4R-0L-4C
S
Prerequisite: AB 210 or consent of instructor
Exploration of the methodologies used to generate systems-level
sets of genetic and protein data, and the tools used to access and
analyze the prodigious amounts of data emerging from such projects.
The application of these technologies to investigate biological
questions and model complex biological systems is also
discussed.
AB 441 Virology 3R-3L-4C
Prerequisite: AB 110 or consent of instructor
Virology focuses on the study of viruses as well as non-viral
entities such as prions and viroids. In this course, students will
learn about the structures, genomes, replication strategies, and
pathogenic mechanisms of various viruses. Viruses causing diseases
of medical and economic importance will be emphasized. In addition,
the techniques used to study viruses and the uses of viruses in the
treatment of disease will be addressed.
AB 451 Cancer Biology 4R-0L-4C
Prerequisite: AB 210 or consent of instructor
This course focuses on cancer at the molecular and cellular level.
Specific cellular molecules and the changes to these cellular
molecules that contribute to transformational and immortalization
of cells and tumor progression will be studied. The mechanisms
behind these molecular changes, cancer promotion and initiation
events, and cancer molecule-specific treatment options will be
addressed. In addition, students will study a variety of specific
cancer types.
AB 461 Evolutionary
Medicine 4R-0L-4C
Arranged Prerequisite: AB 130 and AB 210 or consent of
instructor
This course examines medicine and medical practice from the
perspective of evolutionary constraints, challenges, and diversity.
Topics include theoretical foundations of the field, cancer
patterns, mental health, genetic disease, evolutionary health
promotion, and others.
AB 491 Special Topics in Applied
Biology XR-0L-XC
Arranged Prerequisite: Consent of instructor
Covers upper level material of mutual interest to student and
instructor which cannot be acquired in any other listed AB
course.
AB 492 Directed Study in Applied
Biology XR-XL-XC
Arranged Prerequisite: Consent of instructor
Covers applied biology material of mutual interest to the student
and instructor which cannot be experienced in any other listed AB
course. A student may take between 1-4 credits in any given term,
and a maximum of 8 credits of this course are permitted. Prior
approval of the ABBE department is required to use this course to
fulfill AB elective credit requirements.
AB 499 Senior Thesis Research 0R-12L-4C F, W,
S
Prerequisite: Senior standing
Laboratory research under the direction of a faculty mentor.
Culminates in an oral research presentation and publication of a
Senior Thesis.
Biomedical Engineering
BE 410 Biomedical Engineering Design I 3R-3L-4C
F
Prerequisite: BE 390
This course begins the year-long capstone design project and
continues to investigate the process of design in biomedical
engineering by having student teams initiate the design process for
a relevant problem in biomedical engineering. This includes
developing the design problem from a set of client needs,
establishing specifications, planning the project, scheduling,
efficient use of resources, examining ethics and safety in
engineering design, and working within explicit (or implicit)
constraints such as social, fiscal, manufacturing, etc. The course
culminates with the presentation of the preliminary proposal for
the capstone design project in biomedical engineering.
BE 420 Biomedical Engineering Design II 2R-6L-4C
W
Prerequisite: BE 410
This course is a continuation of BE410 by having student teams
implement their design plan. This will include development of a
test plan, modifications to the design project as needed, and
assessment of design performance relative to initial
specifications. This course culminates in the submission of the
final design document.
BE 430 Biomedical Engineering Design III 1R-3L-2C
S
Prerequisite: BE 420
This course is a continuation of BE 420 and introduces students to
the skills necessary for professional practice in biomedical
engineering including project management, review of critical design
decisions, mentoring design teams, etc. The biomedical
engineering design sequence culminates in the formal oral
presentation of the capstone design report.
BE 435 Biomedical Optics 4R-0L-4C W
Prerequisite: PH 113, MA 222, and SR/GR standing
Optical techniques for biomedical applications and health care;
laser fundamentals, laser interaction with tissues, laser
diagnostics and therapy, laser surgery, endoscopy and applications;
fiber optics; fiber optic biosensors; microscopes; optics- based
clinical applications. Same as OE 435. Students taking BE435/OE435
may not receive credit for BE535/OE535.
BE 482 Bioengineering
Statistics 4R-0L-4C
Prerequisite: MA 223 or MA 382 and consent of
instructor
Hypothesis testing and confidence intervals for two means, two
proportions, and two variances. Introduction to analysis of
variance to include one factor and two factors (with interaction)
designs. Presentation of simple linear and multiple linear
regression modeling; development of analysis of contingency table
to include logistic regression. Presentation of Log odds ratio as
well as several non-parametric techniques of hypothesis testing and
construction of non-parametric confidence intervals and correlation
coefficients. Review of fundamental prerequisite statistics will be
included as necessary. Cross listed with MA 482.
BE 510 Biomedical Signal and Image
Processing 3R-3L-4C W
Prerequisite: BE 201, JR/SR/GR standing or consent of
instructor
Provides a comprehensive survey of signal and image processing
tools for biomedical applications. Major biological signals (e.g.,
ECG), biomedical imaging techniques (e.g., MRI), their origin and
importance, and the commonly used processing techniques with an
emphasis on physiology and diagnostic applications will be
discussed.
BE 511 Human Physiology A 3R-3L-4C F
Prerequisite: JR/SR/GR standing or consent of
instructor
An analysis of neural, muscular, endocrine, reproductive and
digestive physiology from a quantitative, systems-based approach.
Both recent and classical journal articles will be discussed in
class.
BE 512 Human Physiology B 3R-3L-4C W
Prerequisite: JR/SR/GR standing or consent of
instructor
An analysis of cardiovascular, pulmonary, immune and renal
physiology from a quantitative, systems-based approach. Both recent
and classical journal articles will be discussed in class. (Note:
BE511 is not a prerequisite for BE512).
BE 516 Introduction to MEMS: Fabrication and
Applications 3R-3L-4C S
Prerequisite: JR /SR standing
Properties of silicon wafers, wafer-level processes, surface and
bulk micromachining, thin-film deposition, dry and wet etching,
photolithography, process integration, simple actuators.
Introduction to microfluidic systems. MEMS application: capacitive
accelerometer, cantilever and pressure sensor. Students enrolled in
BE516 must do project work on a topic selected by the
instructor.
BE 525 Biomedical Fluid
Mechanics 3R-3L-4C
Prerequisite: EM 301 or CHE 301 or ES 202 or consent of
instructor
Includes cardiovascular physiology, Poiseuille flow, pulsatile
flow in rigid tubes, pulsatile flow in large arteries, blood flow
in the microcirculation, flow and pressure measurement, prosthetic
heart valves, prosthetic arteries, dimensional analysis and
modeling.
BE 531 Biomechanics II 3R-3L-4C S
Prerequisite: BE 331 or consent of instructor
Covers statics, dynamics and deformable body mechanics of
biological systems. Topics include joint anatomy, muscle
physiology, biomechanics of distance running, physiological
response to acceleration, mechanics of bone, joint biomechanics and
selected topics from current literature. The course includes a lab
covering the use of a motion analysis system and force
platforms.
BE 534 Soft Tissue Mechanics 3R-3L-4C S (Even
years)
Prerequisite: EM 203 or EM 204, and BE 331, or consent of
instructor
This course provides an introduction to the various approaches
used in modelling soft tissues, with particular attention paid to
those of the musculoskeletal system (e.g. ligament, tendon,
cartilage). Particular emphasis will be placed on the
theoretical and experimental consequences of the large deformation
behavior of these tissues. This course will serve as a
'Biomechanics' track elective.
BE 535 Biomedical Optics 4R-0L-4C W
Prerequisite: PH 113, MA 222 and SR/GR standing
Optical techniques for biomedical applications and health care;
laser fundamentals, laser interaction with tissues, laser
diagnostics and therapy, laser surgery, endoscopy and applications;
fiber optics; fiber optic biosensors; microscopes; optics-based
clinical applications. For graduate credit, students must do
additional project work on a topic selected by the instructor. Same
as OE 535. Students taking BE535/OE535 may not receive credit for
BE435/OE435.
BE 539 Multiscale Biomechanics 3R-3L-4C S
(Odd years)
Prerequisite: EM 203 or EM 204, and BE 331 or consent of
instructor
This course provides a comprehensive exploration/overview of the
multiple approaches available for the analysis of multiscale media,
beginning from classical approaches in composite theory and moving
on to various structure-function and homogenization models.
Specific attention will be placed on the application of these
ideas to heterogeneous and finite deformation biological tissues
(e.g. bone, cartilage, ligament, vessels, etc.). This
course will serve as a 'Biomechanics' track elective.
BE 541 Medical Imaging 4R-0L-4C
Prerequisite: JR/SR/GR standing or consent of
instructor
Engineering principles of major imaging techniques/modalities for
biomedical applications and health care including computed
tomography, ultrasound, and magnetic resonance imaging. Topics
include general characteristics of medical images; physical
principles and instrumentation of imaging modalities.
Clinical applications of these technologies are also
discussed.
BE 543 Neuroprosthetics 3R-3L-4C
Prerequisite: BE 310 and BE 201
This course takes a detailed look at the state of the art in
Neuroprosthetics design and applications. Topics include
electrode design, sensory prosthetics, functional electrical
stimulation, deep brain stimulation and other contemporary research
topics.
BE 545 Orthopaedic
Biomechanics 3R-3L-4C
Prerequisite: EM 203 or EM 204, and BE 331 or consent of
instructor
This course covers current topics in orthopaedic biomechanics
including the application of solid mechanics principles to
musculoskeletal activities, orthopaedic implants, and fracture
fixation devices. Topics include joint loading; composition and
mechanical behavior of orthopaedic tissues; design/analysis of
artificial joints and fracture fixation prostheses; osteoporosis
and osteoarthritis; and finite element modeling.
BE 550 Research Methods in Biomechanics 3R-3L-4C
W
Prerequisite: BE 330 or consent of instructor
Focuses on the wide range of research methods used in the field of
biomechanics. Current literature will be reviewed to analyze the
advantages and disadvantages of various research methodologies.
Topics will vary based on student interests and background, but may
include topics such as motion/force analysis, soft tissue and bone
mechanics, joint biomechanics, analysis of joint replacements, and
fracture fixation. Laboratory activities will reinforce the lecture
topics and students will have the opportunity to investigate a
biomechanics research topic in their area of interest.
BE 555 Electrophysiology 3R-3L-4C
Prerequisite: JR/SR/GR standing or consent of
instructor
Introduces students to concepts of electrical activity in cells
and organs of the body. Topics include: origin of membrane
potential, membrane channels, synaptic signaling, recording
techniques, gross electrical potentials (e.g. electrocardiogram,
electroencephalogram, electromyogram, electroretinogram). Emphasis
will be placed on how these signals are used to probe physiological
function in the clinic and in the research laboratory.
BE 560 Tissue-Biomaterial Interactions 4R-0L-4C
F
Prerequisite: BE 361 or consent of instructor
Addresses interactions between living cells/tissues and implant
biomaterials, stressing the importance of molecular- and
cellular-level phenomena in initiating and propagating clinically
relevant tissue- and systemic- level results.
BE 570 Introduction to Tissue Engineering 4R-0L-4C
S
Prerequisite: JR/SR/GR standing or consent of
instructor
This course provides a broad overview of the latest developments
in the field of tissue engineering. Normal structure and function
of tissues and organs such as bone, cartilage, nerve, skin, and
liver are discussed. Methods of engineering these tissues, or
encouraging healing or regeneration that would not otherwise occur,
is the focus of the course. The course takes the format of a
graduate seminar, with students taking an active role in presenting
material to the class and leading discussions.
BE 590 Thesis Research F,W,S
Credits as assigned: however, not more than 12 credits will be
applied toward the requirements of an M.S. degree.
BE 597 Selected Topics for Graduate
Students F,W,S
Credits as assigned. Maximum 4 credits per term.
The following courses are offered at the Terre Haute Center for
Medical Education and may be taken for Rose-Hulman credit. To
enroll in these courses RHIT students need permission from the
Chairman of the Department of Applied Biology and Biomedical
Engineering. BE 623 and BE 624 are typically offered in fall
semester and BE 621 and BE 625 are typically offered in spring
semester.
BE 621 Microbiology and Immunology 6
credits
Lectures, conferences and laboratories covering the immune
response as a chemical and cellular Surveillance system; the
consequences of activation of the immune system; and viruses,
bacteria, fungi and protozoan and metazoan parasites as organisms
and as agents of human disease.
BE 623 Gross Anatomy 8 credits
An intensive study of the gross structure of the human body
accomplished through maximum student participation in the
dissection of the human cadaver. Lectures are interpretive and
correlative. Audiovisual supplementation is provided.
BE 624 Biochemistry 6 credits
The chemistry and reactions of constituents of living matter,
including the carbohydrates, lipids, proteins, nucleic acids,
vitamins, coenzymes and minerals; the chemistry and regulation of
the reactions and processes of whole organisms; endocrinology;
enzymology; nutrition; intermediary metabolism; and biochemical
mechanisms in selected disease states.
BE 625 Physiology 8 credits
The course in human physiology covers, in lectures and
laboratories, such topics as circulation, respiration, digestion,
endocrinology, heat metabolism, renal physiology, muscle
physiology, and neurophysiology.
Department
of Applied Biology and Biomedical Engineering
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