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Graduate level course offerings: Biology & Biomedical Engineering

Biology

AB 410 Infection and Immunity 4R-0L-4C
Arranged Prerequisite: AB 110 or consent of instructor
Discussion of various pathogens, how they cause disease, and how they elicit the innate and adaptive immune responses employed to combat them. Cellular and molecular mechanisms of immunity are addressed, as is the epidemiology of various human diseases.

AB 411 Genetic Engineering 4R-0L-4C
Arranged Prerequisite: AB 210 or consent of instructor
Discusses the basics of molecular biology and the genetic and molecular techniques used to engineer prokaryotic and eukaryotic cells, plants, and animals for the production of useful traits or compounds. The application of DNA technology to the diagnosis and treatment of disease is also addressed.

AB 421 Applied Microbiology 4R-0L-4C
Arranged Prerequisite: AB 110 or consent of instructor
Discusses the fundamental biology of microprobes and the processes underlying their use in the production of chemicals, therapeutics and foods. The basics of microbial ecology and the environmental applications of microbial biotechnology are also discussed.

AB 431 Genomics and Proteomics 4R-0L-4C S
Prerequisite: AB 210 or consent of instructor
Exploration of the methodologies used to generate systems-level sets of genetic and protein data, and the tools used to access and analyze the prodigious amounts of data emerging from such projects. The application of these technologies to investigate biological questions and model complex biological systems is also discussed.

AB 441 Virology 3R-3L-4C
Prerequisite: AB 110 or consent of instructor
Virology focuses on the study of viruses as well as non-viral entities such as prions and viroids. In this course, students will learn about the structures, genomes, replication strategies, and pathogenic mechanisms of various viruses. Viruses causing diseases of medical and economic importance will be emphasized. In addition, the techniques used to study viruses and the uses of viruses in the treatment of disease will be addressed.

AB 451 Cancer Biology 4R-0L-4C
Prerequisite: AB 210 or consent of instructor
This course focuses on cancer at the molecular and cellular level. Specific cellular molecules and the changes to these cellular molecules that contribute to transformational and immortalization of cells and tumor progression will be studied. The mechanisms behind these molecular changes, cancer promotion and initiation events, and cancer molecule-specific treatment options will be addressed. In addition, students will study a variety of specific cancer types.

AB 461 Evolutionary Medicine 4R-0L-4C
Arranged Prerequisite: AB 130 and AB 210 or consent of instructor
This course examines medicine and medical practice from the perspective of evolutionary constraints, challenges, and diversity. Topics include theoretical foundations of the field, cancer patterns, mental health, genetic disease, evolutionary health promotion, and others.

AB 491 Special Topics in Applied Biology XR-0L-XC
Arranged Prerequisite: Consent of instructor
Covers upper level material of mutual interest to student and instructor which cannot be acquired in any other listed AB course.

AB 492 Directed Study in Applied Biology XR-XL-XC
Arranged Prerequisite: Consent of instructor
Covers applied biology material of mutual interest to the student and instructor which cannot be experienced in any other listed AB course. A student may take between 1-4 credits in any given term, and a maximum of 8 credits of this course are permitted. Prior approval of the ABBE department is required to use this course to fulfill AB elective credit requirements.

AB 499 Senior Thesis Research 0R-12L-4C F, W, S
Prerequisite: Senior standing
Laboratory research under the direction of a faculty mentor. Culminates in an oral research presentation and publication of a Senior Thesis.

Biomedical Engineering

BE 410 Biomedical Engineering Design I 3R-3L-4C F
Prerequisite: BE 390
This course begins the year-long capstone design project and continues to investigate the process of design in biomedical engineering by having student teams initiate the design process for a relevant problem in biomedical engineering. This includes developing the design problem from a set of client needs, establishing specifications, planning the project, scheduling, efficient use of resources, examining ethics and safety in engineering design, and working within explicit (or implicit) constraints such as social, fiscal, manufacturing, etc. The course culminates with the presentation of the preliminary proposal for the capstone design project in biomedical engineering.

BE 420 Biomedical Engineering Design II 2R-6L-4C W
Prerequisite: BE 410
This course is a continuation of BE410 by having student teams implement their design plan. This will include development of a test plan, modifications to the design project as needed, and assessment of design performance relative to initial specifications. This course culminates in the submission of the final design document.

BE 430 Biomedical Engineering Design III 1R-3L-2C S
Prerequisite: BE 420
This course is a continuation of BE 420 and introduces students to the skills necessary for professional practice in biomedical engineering including project management, review of critical design decisions, mentoring design teams, etc.  The biomedical engineering design sequence culminates in the formal oral presentation of the capstone design report.

BE 435 Biomedical Optics 4R-0L-4C W
Prerequisite: PH 113, MA 222, and SR/GR standing
Optical techniques for biomedical applications and health care; laser fundamentals, laser interaction with tissues, laser diagnostics and therapy, laser surgery, endoscopy and applications; fiber optics; fiber optic biosensors; microscopes; optics- based clinical applications. Same as OE 435. Students taking BE435/OE435 may not receive credit for BE535/OE535.

BE 482 Bioengineering Statistics 4R-0L-4C
Prerequisite: MA 223 or MA 382 and consent of instructor
Hypothesis testing and confidence intervals for two means, two proportions, and two variances. Introduction to analysis of variance to include one factor and two factors (with interaction) designs. Presentation of simple linear and multiple linear regression modeling; development of analysis of contingency table to include logistic regression. Presentation of Log odds ratio as well as several non-parametric techniques of hypothesis testing and construction of non-parametric confidence intervals and correlation coefficients. Review of fundamental prerequisite statistics will be included as necessary. Cross listed with MA 482.

BE 510 Biomedical Signal and Image Processing 3R-3L-4C W
Prerequisite: BE 201, JR/SR/GR standing or consent of instructor
Provides a comprehensive survey of signal and image processing tools for biomedical applications. Major biological signals (e.g., ECG), biomedical imaging techniques (e.g., MRI), their origin and importance, and the commonly used processing techniques with an emphasis on physiology and diagnostic applications will be discussed.

BE 511 Human Physiology A 3R-3L-4C F
Prerequisite: JR/SR/GR standing or consent of instructor
An analysis of neural, muscular, endocrine, reproductive and digestive physiology from a quantitative, systems-based approach. Both recent and classical journal articles will be discussed in class.

BE 512 Human Physiology B 3R-3L-4C W
Prerequisite: JR/SR/GR standing or consent of instructor
An analysis of cardiovascular, pulmonary, immune and renal physiology from a quantitative, systems-based approach. Both recent and classical journal articles will be discussed in class. (Note: BE511 is not a prerequisite for BE512).

BE 516 Introduction to MEMS: Fabrication and Applications 3R-3L-4C S
Prerequisite: JR /SR standing
Properties of silicon wafers, wafer-level processes, surface and bulk micromachining, thin-film deposition, dry and wet etching, photolithography, process integration, simple actuators. Introduction to microfluidic systems. MEMS application: capacitive accelerometer, cantilever and pressure sensor. Students enrolled in BE516 must do project work on a topic selected by the instructor.

BE 525 Biomedical Fluid Mechanics 3R-3L-4C
Prerequisite: EM 301 or CHE 301 or ES 202 or consent of instructor
Includes cardiovascular physiology, Poiseuille flow, pulsatile flow in rigid tubes, pulsatile flow in large arteries, blood flow in the microcirculation, flow and pressure measurement, prosthetic heart valves, prosthetic arteries, dimensional analysis and modeling.

BE 531 Biomechanics II 3R-3L-4C S
Prerequisite: BE 331 or consent of instructor
Covers statics, dynamics and deformable body mechanics of biological systems. Topics include joint anatomy, muscle physiology, biomechanics of distance running, physiological response to acceleration, mechanics of bone, joint biomechanics and selected topics from current literature. The course includes a lab covering the use of a motion analysis system and force platforms.

BE 534 Soft Tissue Mechanics 3R-3L-4C S (Even years)
Prerequisite: EM 203 or EM 204, and BE 331, or consent of instructor
This course provides an introduction to the various approaches used in modelling soft tissues, with particular attention paid to those of the musculoskeletal system (e.g. ligament, tendon, cartilage).  Particular emphasis will be placed on the theoretical and experimental consequences of the large deformation behavior of these tissues. This course will serve as a 'Biomechanics' track elective.

BE 535 Biomedical Optics 4R-0L-4C W
Prerequisite: PH 113, MA 222 and SR/GR standing
Optical techniques for biomedical applications and health care; laser fundamentals, laser interaction with tissues, laser diagnostics and therapy, laser surgery, endoscopy and applications; fiber optics; fiber optic biosensors; microscopes; optics-based clinical applications.  For graduate credit, students must do additional project work on a topic selected by the instructor. Same as OE 535. Students taking BE535/OE535 may not receive credit for BE435/OE435.

BE 539 Multiscale Biomechanics 3R-3L-4C  S (Odd years)
Prerequisite: EM 203 or EM 204, and BE 331 or consent of instructor
This course provides a comprehensive exploration/overview of the multiple approaches available for the analysis of multiscale media, beginning from classical approaches in composite theory and moving on to various structure-function and homogenization models.  Specific attention will be placed on the application of these ideas to heterogeneous and finite deformation biological tissues (e.g. bone, cartilage, ligament, vessels, etc.).    This course will serve as a 'Biomechanics' track elective.

BE 541 Medical Imaging 4R-0L-4C
Prerequisite: JR/SR/GR standing or consent of instructor
Engineering principles of major imaging techniques/modalities for biomedical applications and health care including computed tomography, ultrasound, and magnetic resonance imaging. Topics include general characteristics of medical images; physical principles and instrumentation of imaging modalities.  Clinical applications of these technologies are also discussed.

BE 543 Neuroprosthetics 3R-3L-4C
Prerequisite: BE 310 and BE 201
This course takes a detailed look at the state of the art in Neuroprosthetics design and applications.  Topics include electrode design, sensory prosthetics, functional electrical stimulation, deep brain stimulation and other contemporary research topics.

BE 545 Orthopaedic Biomechanics 3R-3L-4C
Prerequisite: EM 203 or EM 204, and BE 331 or consent of instructor
This course covers current topics in orthopaedic biomechanics including the application of solid mechanics principles to musculoskeletal activities, orthopaedic implants, and fracture fixation devices. Topics include joint loading; composition and mechanical behavior of orthopaedic tissues; design/analysis of artificial joints and fracture fixation prostheses; osteoporosis and osteoarthritis; and finite element modeling.

BE 550 Research Methods in Biomechanics 3R-3L-4C W
Prerequisite: BE 330 or consent of instructor
Focuses on the wide range of research methods used in the field of biomechanics. Current literature will be reviewed to analyze the advantages and disadvantages of various research methodologies. Topics will vary based on student interests and background, but may include topics such as motion/force analysis, soft tissue and bone mechanics, joint biomechanics, analysis of joint replacements, and fracture fixation. Laboratory activities will reinforce the lecture topics and students will have the opportunity to investigate a biomechanics research topic in their area of interest.

BE 555 Electrophysiology 3R-3L-4C
Prerequisite: JR/SR/GR standing or consent of instructor
Introduces students to concepts of electrical activity in cells and organs of the body. Topics include: origin of membrane potential, membrane channels, synaptic signaling, recording techniques, gross electrical potentials (e.g. electrocardiogram, electroencephalogram, electromyogram, electroretinogram). Emphasis will be placed on how these signals are used to probe physiological function in the clinic and in the research laboratory.

BE 560 Tissue-Biomaterial Interactions 4R-0L-4C F
Prerequisite: BE 361 or consent of instructor
Addresses interactions between living cells/tissues and implant biomaterials, stressing the importance of molecular- and cellular-level phenomena in initiating and propagating clinically relevant tissue- and systemic- level results.

BE 570 Introduction to Tissue Engineering 4R-0L-4C S
Prerequisite: JR/SR/GR standing or consent of instructor
This course provides a broad overview of the latest developments in the field of tissue engineering. Normal structure and function of tissues and organs such as bone, cartilage, nerve, skin, and liver are discussed. Methods of engineering these tissues, or encouraging healing or regeneration that would not otherwise occur, is the focus of the course. The course takes the format of a graduate seminar, with students taking an active role in presenting material to the class and leading discussions.

BE 590 Thesis Research F,W,S
Credits as assigned: however, not more than 12 credits will be applied toward the requirements of an M.S. degree.

BE 597 Selected Topics for Graduate Students F,W,S
Credits as assigned. Maximum 4 credits per term.

The following courses are offered at the Terre Haute Center for Medical Education and may be taken for Rose-Hulman credit. To enroll in these courses RHIT students need permission from the Chairman of the Department of Applied Biology and Biomedical Engineering. BE 623 and BE 624 are typically offered in fall semester and BE 621 and BE 625 are typically offered in spring semester.

BE 621 Microbiology and Immunology 6 credits
Lectures, conferences and laboratories covering the immune response as a chemical and cellular Surveillance system; the consequences of activation of the immune system; and viruses, bacteria, fungi and protozoan and metazoan parasites as organisms and as agents of human disease.

BE 623 Gross Anatomy 8 credits
An intensive study of the gross structure of the human body accomplished through maximum student participation in the dissection of the human cadaver. Lectures are interpretive and correlative. Audiovisual supplementation is provided.

BE 624 Biochemistry 6 credits
The chemistry and reactions of constituents of living matter, including the carbohydrates, lipids, proteins, nucleic acids, vitamins, coenzymes and minerals; the chemistry and regulation of the reactions and processes of whole organisms; endocrinology; enzymology; nutrition; intermediary metabolism; and biochemical mechanisms in selected disease states.

BE 625 Physiology 8 credits
The course in human physiology covers, in lectures and laboratories, such topics as circulation, respiration, digestion, endocrinology, heat metabolism, renal physiology, muscle physiology, and neurophysiology.