Biology and Biomedical Engineering Faculty: Ahmed, Anthony, Buckley, Chiu, Coppinger, Dee, Ingram, Livesay, O'Connor,

Biology

BIO 101 Essential Biology   4R-OL-4C  F,W,S  Prereq: None
Surveys basic concepts in the biological sciences and describes how new advances related to these concepts affect contemporary society. Students who have completed BIO110, BIO120 or BIO130 cannot receive credit for taking BIO101.

BIO 102 Nutrition   4R-0L-4C  W  Prereq: None
This course surveys essential concepts in the nutritional sciences, including food composition, diet construction and analysis, physiological processes, and special nutritional needs for certain groups. This course counts as a free elective for BIO or BE majors and not as an BIO elective.

BIO 110 Cell Structure and Function   3R-3L-4C  F,S  Prereq: None
Introduces structures, mechanisms, and laboratory techniques in cellular and molecular biology. Discusses biomolecules, bioenergetics, biosynthesis, enzymatic function, genetics, and cellular regulatory systems.

BIO 120 Comparative Anatomy & Physiology   3R-3L-4C  W  Prereq: None
The structural and functional relationships between tissues and organ systems are discussed using a comparative approach. The lecture is combined with laboratory exercises and observations, which may require dissection of biological specimens.

BIO 130 Evolution and Diversity   3R-3L-4C  S  Prereq: None
Introduces fundamental principles, important applications, and field and laboratory techniques in organismal biology. Discusses mechanisms of evolution, the history of life on earth, biological diversity, and ecology.

BIO 191 Special Topics in Biology   XR-0L-XC  Arranged  Prereq: Consent of instructor
Covers material of mutual interest to students and instructors which cannot be acquired in any other listed BIO course.

BIO 205 Cellular Physiology   4R-0L-4C  F  Prereq: BIO 110
The flow of information in biological systems provides a framework for detailed discussion of cell structure and function, with particular attention paid to the physiology of excitable cells. Cellular communication and the interactions of cells in tissues and the immune system are also examined. Reproduction and organismal development will also be addressed at the cellular level. A student who earns credit for BIO205 cannot earn credit for BIO210 or BIO230 without departmental consent.

BIO 210 Mendelian and Molecular Genetics   3R-3L-4C  F  Prereq: BIO 110 or instructor consent
A discussion of Mendelian genetics including the molecular mechanisms of nuclear and cytoplasmic inheritance. Information flow and control of gene expression are addressed at the molecular level. Basic genetic techniques are covered in both lecture and laboratory.

BIO 220 Prokaryotic Cell and Molecular Biology   3R-3L-4C  W  Prereq: BIO 110 or instructor consent
Discusses the essential properties of eubacteria and archea. Bacterial nutrition, growth, genetics and structural and metabolic diversity are discussed in detail. The basics of virology are also addressed. Fundamental laboratory methodologies are also covered.

BIO 230 Eukaryotic Cell and Molecular Biology   3R-3L-4C  S  Prereq: BIO 110 or instructor consent
Examines the structure and function of various eukaryotic cells. Biomembranes, organelles, the cytoskeleton, energetics, protein sorting, signal transduction and cell interactions are discussed in detail. Essential methods in cell biology are addressed in both lectures and laboratories.

BIO 264 Introduction to Environmental Science   4R-0L-4C  W  Prereq: CHEM 113 and CHEM 113L
This course will introduce students to the broad field of environmental science by examining the biological, chemical, and physical processes that regulate the earths ecosystems and the effect that anthropogenic activity has in disrupting these components on the local and global scale. A final aspect of the course will discuss sustainable human utilization of natural resources. Cross-listed with CHEM 264.

BIO 310 Plant Structure & Function   3R-3L-4C  S  Prereq: BIO 130 or instructor consent
Surveys the structure, physiology, diversity, evolution, and ecological importance of plants and related groups of organisms.

BIO 320 Ecology   3R-3L-4C  F  Prereq: BIO 130 or instructor consent
Surveys adaptations of organisms, population dynamics, species interactions, and the structure and function of natural communities and ecosystems.

BIO 330 Evolutionary Biology   4R-0L-4C  W  Prereq: BIO 130 or instructor consent
Surveys three major themes of evolutionary biology: adaptation, diversity of life, and the shared characteristics of life. Mechanisms of evolution, speciation, phylogeny, and macroevolutionary processes are discussed.

BIO 340 Introduction to Biomedical Research: Clinical Methodology  1R-1L-1C  Prereq: BIO 120, and Jr/Sr standing or consent of instructor
Designed to introduce biology/bioengineering students to the basics of biomedical research using the clinical methodology typical of patient sample analysis. Students will learn to relate testing procedures with specific diseases and to use data obtained from laboratory testing to understand more about specific patient health problems.

BIO 399 Practice of Science   4R-0L-4C  Prereq: RH 330 and MA 223, or consent of instructor
This course focuses on skills required for implementing scientific research, including reading the primary literature, experimental design, scientific writing, oral presentations, research proposal writing, poster presentations, and investigation of research programs (through seminars or individual meetings). Each student chooses a project and research mentor by the end of the course.

BIO 410 Infection and Immunity   4R-0L-4C  Arranged  Prereq: BIO 110 or consent of instructor
Discussion of various pathogens, how they cause disease, and how they elicit the innate and adaptive immune responses employed to combat them. Cellular and molecular mechanisms of immunity are addressed, as is the epidemiology of various human diseases.

BIO 411 Genetic Engineering   4R-0L-4C  Arranged  Prereq: BIO 205 or BIO 210 or consent of instructor
Discusses the basics of molecular biology and the genetic and molecular techniques used to engineer prokaryotic and eukaryotic cells, plants, and animals for the production of useful traits or compounds. The application of DNA technology to the diagnosis and treatment of disease is also addressed.

BIO 421 Applied Microbiology  4R-0L-4C  Arranged  Prereq: BIO 110 or consent of instructor
Discusses the fundamental biology of microprobes and the processes underlying their use in the production of chemicals, therapeutics and foods. The basics of microbial ecology and the environmental applications of microbial biotechnology are also discussed.

BIO 431 Genomics and Proteomics   4R-0L-4C  S  Prereq: BIO 205 or BIO 210 or consent of instructor
Exploration of the methodologies used to generate systems-level sets of genetic and protein data, and the tools used to access and analyze the prodigious amounts of data emerging from such projects. The application of these technologies to investigate biological questions and model complex biological systems is also discussed.

BIO 441 Virology   3R-3L-4C  Prereq: BIO 110, or consent of instructor
Virology focuses on the study of viruses as well as non-viral entities such as prions and viroids. In this course, students will learn about the structures, genomes, replication strategies, and pathogenic mechanisms of various viruses. Viruses causing diseases of medical and economic importance will be emphasized. In addition, the techniques used to study viruses and the uses of viruses in the treatment of disease will be addressed.

BIO 451 Cancer Biology   4R-0L-4C  Prereq: BIO 205 or BIO 210 or consent of instructor
This course focuses on cancer at the molecular and cellular level. Specific cellular molecules and the changes to these cellular molecules that contribute to transformational and immortalization of cells and tumor progression will be studied. The mechanisms behind these molecular changes, cancer promotion and initiation events, and cancer molecule-specific treatment options will be addressed. In addition, students will study a variety of specific cancer types.

BIO 461 Evolutionary Medicine   4R-0L-4C  Arranged  Prereq: BIO 130, and BIO 205 or BIO 210, or instructor consent.
This course examines medicine and medical practice from the perspective of evolutionary constraints, challenges, and diversity. Topics include theoretical foundations of the field, cancer patterns, mental health, genetic disease, evolutionary health promotion, and others.

BIO 471 Genetic and Molecular Analysis of Inherited Human Disease   4R-0L-4C  S  Arranged  Prereq: BIO 205 or BIO 210 or consent of instructor
Strategies and methods used to identify and understand the genetic and molecular bases of inherited human disease are addressed. Topics include, human population genetics, pedigrees, genetic and physical mapping of human genes, linkage analysis, and diagnostic testing. Primary literature is routinely utilized.

BIO 491 Special Topics in Biology   XR-0L-XC  Arranged  Prereq: Consent of instructor
Covers upper level material of mutual interest to student and instructor which cannot be acquired in any other listed BIO course.

BIO 492 Directed Study in Biology   XR-XL-XC  Arranged  Prereq: Consent of instructor
Covers biology material of mutual interest to the student and instructor which cannot be experienced in any other listed BIO course. A student may take between 1-4 credits in any given term, and a maximum of 8 credits of this course are permitted. Prior approval of the BBE department is required to use this course to fulfill BIO elective credit requirements.

BIO 496 Senior Thesis Research I   0R-6L-2C  F,W,S  Prereq: BIO 399 and consent of instructor
Initiation of senior thesis under the direction of an BBE faculty mentor. Major tasks include creation and submission of a research proposal and piloting procedures. Additional requirements for adequate progress determined by each faculty mentor.

BIO 497 Senior Thesis Research II   0R-12L-4C  F,W,S  Prereq: BIO 399 and consent of instructor
Continuation of research under the direction of an BBE faculty mentor. Major tasks include data acquisition and methodological refinement. Additional requirements for adequate progess determined by each faculty mentor.

BIO 498 Senior Thesis Research III   0R-12L-4C  F,W,S  Prereq: BIO 399 and consent of instructor
Continuation of research under the direction of an BBE faculty mentor. Major tasks include data acquisition and preliminary analysis. Additional requirements for adequate progress determined by each faculty mentor.

BIO 499 Senior Thesis Research IV   0R-6L-2C  W  Prereq: BIO 399 and consent of instructor
Completion of senior thesis under the direction of an BBE faculty mentor. Major tasks include final analysis, public presentation of results, and submission of the written thesis. Additional requirements for adequate progress determined by each faculty mentor.

Biomedical Engineering

BE 100 Problem Solving in the Biological Sciences and Engineering   3R-3L-4C  S  Prereq: None
This course introduces students to computational tools for solving problems in biology and biomedical engineering. The primary thrust of the course is structured programming in MatLab. In addition, we will explore data description, the proper presentation of data, effective use of spreadsheet tools in data analysis, structured programming, and an introduction to bioinformatics and Working Model.

BE 201 Biomedical Measurements   3R-3L-4C  W, S  Prereq: BE 100, ES 203
Discussion of measurement principles for biomedical engineering. Topics include op-amp circuit analysis, frequency analysis, fundamentals of digital gates and flip-flops, different types of biomedical sensors (temperature, force, pressure, velocity, etc), and basics of microcontrollers and embedded system.

BE 310 Analysis of Physiological Systems I   3R-3L-4C  W  Prereq: BIO 120, BIO 205
An analysis of neural, muscular, and endocrine physiology from a quantitative, systems-based approach.

BE 317 Design for Biomedical Manufacturing   1R-0L-1C  W  Prereq: EM 104
This BE course is to be taken concurrently with ME317, Design for Manufacturing. This course presents manufacturing methods associated with biomedical products and situates Design for Manufacturing within the larger context of cradle to cradle design processes. Current biomedical industry processes and issues are emphasized. Taking ME317 and BE317 simultaneously, and passing both courses, will fulfill the requirement for a 4-credit BE biomechanics or biomaterials concentration elective.

BE 320 Analysis of Physiological Systems II   3R-3L-4C  S  Prereq: BE310
An analysis of cardiovascular, pulmonary, and renal physiology from a quantitative, systems-based approach.

BE 331 Biomechanics  3R-0L-3C W  Prereq: ES 201, EM 204, and BE 201, or consent of instructor Co: BE 351 or BE352, and BE 361
This course introduces students to the various interdisciplinary fields in biomechanics - such as orthopaedic biomechanics, biofluid mechanics, soft tissue mechanics, and the biomechanics of human movement. Specific topics include: statics/dynamics of the human body, kinematics during activity; the analysis of forces and stresses/strains in biological structures under loading; constitutive models for biological materials (e.g. bone, cartilage, tendon/ligament); and the relationship between structure and function in tissues and organs. Non-majors interested in taking this course should see the instructor.

BE 340 Biomedical Instrumentation and Signal Processing   3R-3L-4C  F  Prereq: BE 201, ES 203
This course introduces the fundamental of biomedical signal processing strategies. Topics include data acquisition, A/D and D/A conversion, digital filter design, time-frequency analysis, and I/O interfaces. Multichannel data processing and high dimensional data analysis techniques are also covered. Lectures will be accompanied by data analysis assignments and projects using MATLAB, LabVIEW, and microcontrollers.

BE 350 Biocontrol Systems   4R-0L-4C  Prereq: ES 205
Systems representation and analysis in the frequency and time domain. Topics include Laplace transforms, modeling of electrical and mechanical systems, stability, steady-state error analysis, root locus design, frequency response analysis, and applications in physiology and medicine.

BE 351 Biomedical Engineering Lab   1R-3L-2C  Coreq: BE 331 and BE 361
This course emphasizes the fundamental concepts in biomechanics and biomaterials through hands-on experience with standard testing equipment. Laboratory projects will be assigned which will require the students to use basic instrumentation to determine and execute effective test methods. Non-majors interested in taking this course should see the instructor

BE 352 Biomechanics Lab   0R-3L-1C Pre: ES 201, EM 204, and BE 201, or consent of instructor. Coreq: BE 331
This course emphasizes the fundamental concepts in biomechanics through hands-on experience with standard testing equipment. Laboratory projects will be assigned which will require the students to use basic instrumentation to determine and execute effective test methods.

BE 353 Biomaterials Lab   0R-3L-1C  Prereq: ES 201, EM 204, and BE 201, or consent of instructor. Coreq: BE 361
This course emphasizes the fundamental concepts in biomaterials through hands-on experience with standard testing equipment. Laboratory projects will be assigned which will require the students to use basic instrumentation to determine and execute effective test methods.

BE 361 Biomaterials   3R-0L-3C  W
Structure-property relationships for metallic, polymeric, and ceramic biomaterials. Study of the interactions of these materials with the body and factors affecting the selection and design of materials for medical implants and devices.

BE 385 Quality Methods   4R-0L-4C  S  Prereq: MA 223 or MA 382
Introduction to various aspects of statistical quality control and statistical process control to include the following topics: importance of variance reduction and probability concepts influencing product quality and reliability; development and application of control charts (Pcharts, NP-charts, C-charts, U-charts, individual’s charts, moving range charts, X-bar and R as well as X-bar and S charts); process capability indices (their use and misuse); introduction to acceptance sampling. Other topics to be included as time allows: 6 sigma thinking, gauge reproducibility and repeatability, and total quality management with the philosophies of Deming, Juran, and Crosby. Review of fundamental prerequisite statistics will be included as necessary. Same as MA 385

BE 390 Principles of Biomedical Engineering Design   1R-3L-2C  S  Prereq: BE 201, Coreq: EM 204, or consent of instructor
In this course, junior BE majors are introduced to the engineering design methodology as utilized in biomedical engineering. Students will learn engineering design through completion of a team design project with realistic constraints. This course serves as the entry point for the four-quarter sequence in which students undertake and complete their capstone design project.

BE 400 Consulting Engineering Seminar   2R-0L-2C  S  Prereq: Junior class standing
Discusses problems in the field of consulting engineering; includes seminars presented by practicing consulting engineers and a suitable project to practice consulting skills. Cross-listed with CE420, ME420, CHE420, ECE466.

BE 410 Biomedical Engineering Design I   3R-3L-4C  F  Prereq: BE 390
This course begins the year-long capstone design project and continues to investigate the process of design in biomedical engineering by having student teams initiate the design process for a relevant problem in biomedical engineering. This includes developing the design problem from a set of client needs, establishing specifications, planning the project, scheduling, efficient use of resources, examining ethics and safety in engineering design, and working within explicit (or implicit) constraints such as social, fiscal, manufacturing, etc. The course culminates with the presentation of the preliminary proposal for the capstone design project in biomedical engineering.

BE 420 Biomedical Engineering Design II   2R-6L-4C  W  Prereq: BE 410
This course is a continuation of BE410 by having student teams implement their design plan. This will include development of a test plan, modifications to the design project as needed, and assessment of design performance relative to initial specifications. This course culminates in the submission of the final design document.

BE 430 Biomedical Engineering Design III   1R-3L-2C  S  Prereq: BE 420
This course is a continuation of BE420 and introduces students to the skills necessary for professional practice in biomedical engineering including project management, review of critical design decisions, mentoring design teams, etc. The biomedical engineering design sequence culminates in the formal oral presentation of the capstone design report.

BE 435 Biomedical Optics   3.5R-1.5L-4C  Prereq: PH 113, MA 222 or SR/GR standing or consent of instructor
Optical techniques for biomedical applications and health care; laser fundamentals, laser interaction with biological cells, organelles and nanostructures; laser diagnostics and therapy, laser surgery; microscopes; optics-based clinical applications; imaging and spectroscopy, biophotonics laboratories. For graduate credit, students must do additional project work on a topic selected by the instructor. Cross-listed with OE 435.

BE 482 Bioengineering Statistics   4R-0L-4C  Prereq: MA 223 or MA 382 and consent of instructor (cross listed with MA 482)
Hypothesis testing and confidence intervals for two means, two proportions, and two variances. Introduction to analysis of variance to include one factor and two factors (with interaction) designs. Presentation of simple linear and multiple linear regression modeling; development of analysis of contingency table to include logistic regression. Presentation of Log odds ratio as well as several non-parametric techniques of hypothesis testing and construction of non-parametric confidence intervals and correlation coefficients. Review of fundamental prerequisite statistics will be included as necessary.

BE 491 Special Topics in Biomedical Engineering   XR-0L-XC  Arranged  Prereq: Consent of instructor
Covers upper-level, undergraduate material of mutual interest to student and instructor which cannot be acquired in any other listed undergraduate BE course.

BE492 Directed Study in Biomedical Engineering   XR-XL-XC  Arranged  Prereq: Consent of instructor
Covers biomedical engineering material of mutual interest to the student and instructor which cannot be experienced in any other listed BE course. A student may take between 1-4 credits in any given term.

BE 499 Thesis Research   0R-6L-2C  F,W,S  Prereq: Junior or senior standing
Culmination of biomedical engineering thesis research in which a student writes and
submits the senior thesis, following departmentally established guidelines, and gives an
oral research presentation to at least three departmental faculty members, including the
student's advisor. BE499 may not be used as a biomedical engineering area elective.

BE 510 Biomedical Signal and Image Processing   3R-3L-4C  W  Prereq: BE201, JR, SR or Graduate standing or consent of instructor
Provides a comprehensive survey of signal and image processing tools for biomedical applications. Major biological signals (e.g., ECG), biomedical imaging techniques (e.g., MRI), their origin and importance, and the commonly used processing techniques with an emphasis on physiology and diagnostic applications will be discussed.

BE 511 Analysis of Physiological Systems I   3R-3L-4C  W  Prereq: Junior, Senior, Graduate standing or consent of instructor
An analysis of neural, muscular, endocrine, and digestive physiology from a quantitative, systems-based approach. Both recent and classical journal articles will be discussed in class. Students enrolled in BE511 must complete a project not covered in BE310. Students may not receive credit for both BE511 and BE310.

BE 512 Analysis of Physiological Systems II   3R-3L-4C  S  Prereq: Graduate standing or consent of instructor
An analysis of cardiovascular, pulmonary, and renal physiology from a quantitative, systems-based approach. Both recent and classical journal articles will be discussed in class. (Note: BE511 is not a prerequisite for BE512). Students enrolled in BE512 must complete a project not covered in BE320. Students may not receive credit for both BE512 and BE320.

BE 516 Introduction to MEMS: Fabrication and Applications   3R-3L-4C  S  Prereq: JR or SR standing
Properties of silicon wafers, wafer-level processes, surface and bulk micromachining, thin-film deposition, dry and wet etching, photolithography, process integration, simple actuators. Introduction to microfluidic systems. MEMS application: capacitive accelerometer, cantilever and pressure sensor. Students enrolled in BE516 must do project work on a topic selected by the instructor. Cross-listed with CHE 505, ECE 516, EP 510, and ME 516.

BE 520 Introduction to Brain Machine Interfaces   3R-3L-4C  S  Prereq: BE340 or ECE480
This course is an introduction to the basics of motor cortical functions related to voluntary and imagery movements, evoked response potentials, invasive vs. noninvasive electrode design considerations, quantitative EEG analysis techniques used in clinical settings, and the applications of brain-machine interfaces/brain-computer interfaces in the restoration of mobility, communication and motor function.

BE 525 Biomedical Fluid Mechanics   3R-3L-4C  Prereq: EM 301 or CHE 301 or ES202 or consent of instructor
Includes cardiovascular physiology, Poiseuille flow, pulsatile flow in rigid tubes, pulsatile flow in large arteries, blood flow in the microcirculation, flow and pressure measurement, prosthetic heart valves, prosthetic arteries, dimensional analysis and modeling.

BE 531 Biomechanics II   3R-3L-4C  Prereq: BE331 or consent of instructor
Covers statics, dynamics and deformable body mechanics of biological systems. Topics include joint anatomy, muscle physiology, biomechanics of distance running, physiological response to acceleration, mechanics of bone, joint biomechanics and selected topics from current literature. The course includes a lab covering the use of a motion analysis system and force platforms.

BE 534 Soft Tissue Mechanics 3 R-3L-4C  Prereq: EM 203 or EM 204, and BE 331, or consent of instructor
This course provides an introduction to the various approaches used in modelling soft tissues, with particular attention paid to those of the musculoskeletal system (e.g. ligament, tendon, cartilage). Particular emphasis will be placed on the theoretical and experimental consequences of the large deformation behavior of these tissues. This course will serve as a Biomechanics track elective.

BE 535 Biomedical Optics   3.5R-1.5L-4C  Prereq: PH 113, MA 222 or SR/GR standing or consent of instructor
Optical techniques for biomedical applications and health care; laser fundamentals, laser interaction with biological cells, organelles and nanostructures; laser diagnostics and therapy, laser surgery; microscopes; optics-based clinical applications; imaging and spectroscopy, biophotonics laboratories. For graduate credit, students must do additional project work on a topic selected by the instructor. Cross-listed with OE 535.

BE 539 Multiscale Biomechanics   3R-3L-4C  Prereq: EM 203 or EM 204, and BE 331, or consent of instructor
This course provides a comprehensive exploration/overview of the multiple approaches available for the analysis of multiscale media, beginning from classical approaches in composite theory and moving on to various structure-function and homogenization models. Specific attention will be placed on the application of these ideas to heterogeneous and finite deformation biological tissues (e.g. bone, cartilage, ligament, vessels, etc.). This course will serve as a Biomechanics track elective.

BE 541 Medical Imaging Systems  4R-0L-4C  Prereq: Graduate standing and BE340, or BE340 with a grade of B or better, or consent of instructor.
Engineering principles of major imaging techniques/modalities for biomedical applications and health care including diagnostic x-ray, computed tomography, nuclear techniques, ultrasound, and magnetic resonance imaging. Topics include general characteristics of medical images; physical principles, signal processing to generate an image, and instrumentation of imaging modalities. Clinical applications of these technologies are also discussed.  Same as ECE584.

BE 543 Neuroprosthetics   3R-3L-4C  Prereq: BE310 and BE201
This course takes a detailed look at the state of the art in Neuroprosthetics design and applications. Topics include electrode design, sensory prosthetics, functional electrical stimulation, deep brain stimulation and other contemporary research topics.

BE 545 Orthopaedic Biomechanics   4R-0L-4C  Prereq: EM 203 or EM 204, and BE 331 or consent of instructor
This course covers current topics in orthopaedic biomechanics including the application of solid mechanics principles to musculoskeletal activities, orthopaedic implants, and fracture fixation devices. Topics include joint loading; composition and mechanical behavior of orthopaedic tissues; design/analysis of artificial joints and fracture fixation prostheses; osteoporosis and osteoarthritis; and finite element modeling.

BE 550 Research Methods in Biomechanics   3R-3L-4C  W  Prereq: BE 331 or consent of instructor
Focuses on the wide range of research methods used in the field of biomechanics. Current literature will be reviewed to analyze the advantages and disadvantages of various research methodologies. Topics will vary based on student interests and background, but may include topics such as motion/force analysis, soft tissue and bone mechanics, joint biomechanics, analysis of joint replacements, and fracture fixation. Laboratory activities will reinforce the lecture topics and students will have the opportunity to investigate a biomechanics research topic in their area of interest.

BE 555 Electrophysiology   3R-3L-4C  Prereq: Junior, Senior, Graduate standing or consent of instructor
Introduces students to concepts of electrical activity in cells and organs of the body. Topics include: origin of membrane potential, membrane channels, synaptic signaling, recording techniques, gross electrical potentials (e.g. electrocardiogram, electroencephalogram, electromyogram, electroretinogram). Emphasis will be placed on how these signals are used to probe physiological function in the clinic and in the research laboratory.

BE 560: Tissue-Biomaterial Interactions   4R-0L-4C  Prereq: BE 361, or consent of instructor
Addresses interactions between living cells/tissues and implant biomaterials, stressing the importance of molecular- and cellular-level phenomena in initiating and propagating clinically relevant tissue- and systemic- level results.

BE 565 Experimental Methods in Tissue-Biomaterial Interactions   3R-3L-4C  S  Prereq: BE 361, or consent of instructor
This course focuses on teaching students experimental methods used for investigations of tissue-biomaterial interactions. Topics include bioethics issues associated with experiments on cells, tissues, animals, and people; biosafety issues associated with cells/tissues from animals and humans; the design, critique, and statistical analysis of experiments. Students conduct hands-on investigations of cell-biomaterial interactions which require the use of common laboratory equipment, aseptic technique, mammalian cell culture, and current molecular methods to investigate cell viability, structure, and function.

BE 570 Introduction to Tissue Engineering   4R-0L-4C  Prereq: Junior, Senior, or Graduate standing or permission of instructor
This course provides a broad overview of the latest developments in the field of tissue engineering. Normal structure and function of tissues and organs such as bone, cartilage, nerve, skin, and liver are discussed. Methods of engineering these tissues, or encouraging healing or regeneration that would not otherwise occur, is the focus of the course. The course takes the format of a graduate seminar, with students taking an active role in presenting material to the class and leading discussions.

BE 590 Thesis Research   F,W,S
Credits as assigned: however, not more than 12 credits will be applied toward the requirements of an M.S. degree.

BE 597 Selected Topics   F,W,S
Selected Topics for Graduate Students Credits as assigned. Maximum 4 credits per term.


The following courses are offered at the Terre Haute Center for Medical Education and may be taken for Rose-Hulman credit. To enroll in these courses RHIT students need permission from the Chairman of the Department of Applied Biology and Biomedical Engineering. BE 623 and BE 624 are typically offered in fall semester and BE 621 and BE 625 are typically offered in spring semester.

BE 621 Microbiology and Immunology (6 cr.)
Lectures, conferences and laboratories covering the immune response as a chemical and cellular Surveillance system; the consequences of activation of the immune system; and viruses, bacteria, fungi and protozoan and metazoan parasites as organisms and as agents of human disease.

BE 623 Gross Anatomy (8 cr.)
An intensive study of the gross structure of the human body accomplished through maximum student participation in the dissection of the human cadaver. Lectures are interpretive and correlative. Audiovisual supplementation is provided.

BE 624 Biochemistry (6 cr.)
The chemistry and reactions of constituents of living matter, including the carbohydrates, lipids, proteins, nucleic acids, vitamins, coenzymes and minerals; the chemistry and regulation of the reactions and processes of whole organisms; endocrinology; enzymology; nutrition; intermediary metabolism; and biochemical mechanisms in selected disease states.

BE 625 Physiology (8 cr.)
The course in human physiology covers, in lectures and laboratories, such topics as circulation, respiration, digestion, endocrinology, heat metabolism, renal physiology, muscle physiology, and neurophysiology.