Applied Biology and Biomedical Engineering Faculty: Ahmed, Anthony, Buckley, Coppinger, Dee, Ingram, Livesay, O'Connor, Rogge, Waite, Weiner, Xu

Applied Biology

AB 101 Essential Biology 4R-OL-4C F,W,S Pre: None 
Surveys basic concepts in the biological sciences and describes how new advances related to these concepts affect contemporary society. Students who have completed AB110, AB120 or AB130 cannot receive credit for taking AB101.

AB 102 Nutrition   4R-0L-4C W  Pre: none
This course surveys essential concepts in the nutritional sciences, including food composition, diet construction and analysis, physiological processes, and special nutritional needs for certain groups. This course counts as a free elective for AB or BE majors and not as an AB elective.

AB 110 Cell Structure and Function 3R-3L-4C F,S Pre: None
Introduces structures, mechanisms, and laboratory techniques in cellular and molecular biology. Discusses biomolecules, bioenergetics, biosynthesis, enzymatic function, genetics, and cellular regulatory systems.

AB 120 Comparative Anatomy & Physiology 3R-3L-4C W Pre: None
The structural and functional relationships between tissues and organ systems are discussed using a comparative approach. The lecture is combined with laboratory exercises and observations, which may require dissection of biological specimens.

AB 130 Evolution and Diversity 3R-3L-4C S Pre: None
Introduces fundamental principles, important applications, and field and laboratory techniques in organismal biology. Discusses mechanisms of evolution, the history of life on earth, biological diversity, and ecology.

AB 191 Special Topics in Applied Biology XR-0L-XC Arranged Pre: Consent of instructor
Covers material of mutual interest to students and instructors which cannot be acquired in any other listed AB course.

AB 210 Mendelian and Molecular Genetics 3R-3L-4C F Pre: AB 110 or instructor consent 
A discussion of Mendelian genetics including the molecular mechanisms of nuclear and cytoplasmic inheritance. Information flow and control of gene expression are addressed at the molecular level. Basic genetic techniques are covered in both lecture and laboratory.

AB 220 Prokaryotic Cell and Molecular Biology 3R-3L-4C W Pre: AB 110 or instructor consent 
Discusses the essential properties of eubacteria and archea. Bacterial nutrition, growth, genetics and structural and metabolic diversity are discussed in detail. The basics of virology are also addressed. Fundamental laboratory methodologies are also covered.

AB 230 Eukaryotic Cell and Molecular Biology 3R-3L-4C S Pre: AB 110 or instructor consent
Examines the structure and function of various eukaryotic cells. Biomembranes, organelles, the cytoskeleton, energetics, protein sorting, signal transduction and cell interactions are discussed in detail. Essential methods in cell biology are addressed in both lectures and laboratories.

AB 264 Introduction to Environmental Science 4R-0L-4C W Pre: CHEM 111, or CHEM 105 or CHEM 201, or consent of instructor
This course will introduce students to the broad field of environmental science by examining the biological, chemical, and physical processes that regulate the earths ecosystems and the effect that anthropogenic activity has in disrupting these components on the local and global scale. A final aspect of the course will discuss sustainable human utilization of natural resources. Cross-listed with CHEM 264.

AB 301, 302 Biology Colloquium 1R-0L-1C F, W Pre: Junior standing 
A discussion of selected timely topics and preparation for senior research.

AB 310 Plant Structure & Function 3R-3L-4C S Pre: AB 130 or instructor consent 
Surveys the structure, physiology, diversity, evolution, and ecological importance of plants and related groups of organisms.

AB 320 Ecology 3R-3L-4C F Pre: AB 130 or instructor consent 
Surveys adaptations of organisms, population dynamics, species interactions, and the structure and function of natural communities and ecosystems.

AB 330 Evolutionary Biology 4R-0L-4C W Pre: AB 130 or instructor consent 
Surveys three major themes of evolutionary biology: adaptation, diversity of life, and the shared characteristics of life. Mechanisms of evolution, speciation, phylogeny, and macroevolutionary processes are discussed.

AB 340 Introduction to Biomedical Research: Clinical Methodology 1R-1L-1C Pre: AB120, and Jr/Sr standing or consent of instructor
Designed to introduce applied biology/bioengineering students to the basics of biomedical research using the clinical methodology typical of patient sample analysis. Students will learn to relate testing procedures with specific diseases and to use data obtained from laboratory testing to understand more about specific patient health problems.

AB 401 Biology Colloquium 2R-0L-2C W Pre: Senior standing
Oral presentations and discussion of selected timely topics.

AB 410 Infection and Immunity 4R-0L-4C Arranged Pre: AB 110 or consent of instructor
Discussion of various pathogens, how they cause disease, and how they elicit the innate and adaptive immune responses employed to combat them. Cellular and molecular mechanisms of immunity are addressed, as is the epidemiology of various human diseases.

AB 411 Genetic Engineering 4R-0L-4C Arranged Pre: AB 210 or consent of instructor
Discusses the basics of molecular biology and the genetic and molecular techniques used to engineer prokaryotic and eukaryotic cells, plants, and animals for the production of useful traits or compounds. The application of DNA technology to the diagnosis and treatment of disease is also addressed.

AB 421 Applied Microbiology 4R-0L-4C Arranged Pre: AB110 or consent of instructor
Discusses the fundamental biology of microprobes and the processes underlying their use in the production of chemicals, therapeutics and foods. The basics of microbial ecology and the environmental applications of microbial biotechnology are also discussed.

AB 431 Genomics and Proteomics 4R-0L-4C S Pre: AB210 or consent of instructor 
Exploration of the methodologies used to generate systems-level sets of genetic and protein data, and the tools used to access and analyze the prodigious amounts of data emerging from such projects. The application of these technologies to investigate biological questions and model complex biological systems is also discussed.

AB 441 Virology 3R-3L-4C Pre: AB110, or consent of instructor
Virology focuses on the study of viruses as well as non-viral entities such as prions and viroids. In this course, students will learn about the structures, genomes, replication strategies, and pathogenic mechanisms of various viruses. Viruses causing diseases of medical and economic importance will be emphasized. In addition, the techniques used to study viruses and the uses of viruses in the treatment of disease will be addressed.

AB 451 Cancer Biology 4R-0L-4C Pre: AB210, or consent of instructor
This course focuses on cancer at the molecular and cellular level. Specific cellular molecules and the changes to these cellular molecules that contribute to transformational and immortalization of cells and tumor progression will be studied. The mechanisms behind these molecular changes, cancer promotion and initiation events, and cancer molecule-specific treatment options will be addressed. In addition, students will study a variety of specific cancer types.

AB 461 Evolutionary Medicine 4R-0L-4C Arranged Pre: AB130 and AB210, or instructor consent.
This course examines medicine and medical practice from the perspective of evolutionary constraints, challenges, and diversity. Topics include theoretical foundations of the field, cancer patterns, mental health, genetic disease, evolutionary health promotion, and others.

AB 491 Special Topics in Applied Biology XR-0L-XC Arranged Pre: Consent of instructor 
Covers upper level material of mutual interest to student and instructor which cannot be acquired in any other listed AB course.

AB 492 Directed Study in Applied Biology XR-XL-XC Arranged Pre: Consent of instructor
Covers applied biology material of mutual interest to the student and instructor which cannot be experienced in any other listed AB course. A student may take between 1-4 credits in any given term, and a maximum of 8 credits of this course are permitted. Prior approval of the ABBE department is required to use this course to fulfill AB elective credit requirements.

AB 499 Senior Thesis Research 0R-12L-4C F, W, S Pre: Senior standing 
Laboratory research under the direction of a faculty mentor. Culminates in an oral research presentation and publication of a Senior Thesis.

Biomedical Engineering

BE 100 Problem Solving in the Biological Sciences and Engineering 3R-3L-4C   W   Pre: None 
This course introduces students to computational tools for solving problems in biology and biomedical engineering.  The primary thrust of the course is structured programming in MatLab.  In addition, we will explore data description, the proper presentation of data, effective use of spreadsheet tools in data analysis, structured programming, and an introduction to bioinformatics and Working Model.

BE201 Biomedical Measurements 3R-3L-4C Pre: BE100, ES203
Discuss the measurement principles for biomedical engineering. Topics include op-amp circuit analysis, frequency analysis, fundamentals of digital gates and flip-flops, different types of biomedical sensors (temperature, force, pressure, velocity, etc), and basics of PIC microcontrollers and embedded system.

BE 310 Analysis of Physiological Systems  I:   3R-3L-4C   F   Pre: AB120
An analysis of neural, muscular, endocrine, reproductive and digestive physiology from a quantitative, systems-based approach.

BE 317 Design for Biomedical Manufacturing 1R-0L-1C W Pre: EM 104 
This BE course is to be taken concurrently with ME317, Design for Manufacturing.  This course presents manufacturing methods associated with biomedical products and situates Design for Manufacturing within the larger context of "cradle to cradle" design processes.  Current biomedical industry processes and issues are emphasized.  Taking ME317 and BE317 simultaneously, and passing both courses, will fulfill the requirement for a 4-credit BE biomechanics or biomaterials concentration elective.

BE 320 Analysis of Physiological Systems II:  3R-3L-4C   W     Pre: BE310
An analysis of cardiovascular, pulmonary, immune and renal physiology from a quantitative, systems-based approach.

BE 331 Biomechanics 3R-0L-3C  C  W   Pre: ES 201, EM 204, and BE 201, or consent of instructor Co: BE351 and BE361
This course introduces students to the various interdisciplinary fields in biomechanics - such as orthopaedic biomechanics, biofluid mechanics, soft tissue mechanics, and the biomechanics of human movement.  Specific topics include: statics/dynamics of the human body, kinematics during activity; the analysis of forces and stresses/strains in biological structures under loading; constitutive models for biological materials (e.g. bone, cartilage, tendon/ligament); and the relationship between structure and function in tissues and organs. Non-majors interested in taking this course should see the instructor.

BE 340 Biomedical Instrumentation and Signal Processing 3R-3L-4C F Pre: Pre: BE 201 and ES 203, or consent of instructor
Topics include Circuit analysis, frequency analysis, biomedical transducers, design of biomedical devices, and introduction to imaging techniques.

BE 350 Biocontrol Systems 4R-0L-4C W Pre: ES 205
Systems representation and analysis in the frequency and time domain.  Topics include Laplace transforms, modeling of electrical and mechanical systems, stability, steady-state error analysis, root locus design, frequency response analysis, and applications in physiology and medicine.

BE351: Biomedical Engineering Lab 1R-3L-2C Pre: ES 201, EM 204, and BE 201, or consent of instructor Co: BE331 and BE361
This course emphasizes the fundamental concepts in biomechanics and biomaterials through hands-on experience with standard testing equipment.  Laboratory projects will be assigned which will require the students to use basic instrumentation to determine and execute effective test methods.  Non-majors interested in taking this course should see the instructor

BE352: Biomechanics Lab 0R-3L-1C Pre: ES 201, EM 204, and BE 201, or consent of instructor Co: BE331
This course emphasizes the fundamental concepts in biomechanics through hands-on experience with standard testing equipment.  Laboratory projects will be assigned which will require the students to use basic instrumentation to determine and execute effective test methods. 

BE353: Biomaterials Lab 0R-3L-1C Pre: ES 201, EM 204, and BE 201, or consent of instructor Co: BE361
This course emphasizes the fundamental concepts in biomaterials through hands-on experience with standard testing equipment.  Laboratory projects will be assigned which will require the students to use basic instrumentation to determine and execute effective test methods. 

BE 361 Biomaterials 3R-0L-3C W 
Structure-property relationships for metallic, polymeric, and ceramic biomaterials.  Study of the interactions of these materials with the body and factors affecting the selection and design of materials for medical implants and devices.

BE 390 Principles of Biomedical Engineering Design  1R-3L-2C  S  Pre: BE 201, Coreq: EM204, or consent of instructor
In this course, junior BE majors are introduced to the engineering design methodology as utilized in biomedical engineering.  Students will learn engineering design through completion of a team design project with realistic constraints. This course serves as the entry point for the four-quarter sequence in which students undertake and complete their capstone design project.

BE 410 Biomedical Engineering Design I  3R-3L-4C  F  Pre: BE390
This course begins the year-long capstone design project and continues to investigate the process of design in biomedical engineering by having student teams initiate the design process for a relevant problem in biomedical engineering. This includes developing the design problem from a set of client needs, establishing specifications, planning the project, scheduling, efficient use of resources, examining ethics and safety in engineering design, and working within explicit (or implicit) constraints such as social, fiscal, manufacturing, etc.  The course culminates with the presentation of the preliminary proposal for the capstone design project in biomedical engineering.

BE 420 Biomedical Engineering Design II  2R-6L-4C  W  Pre: BE410
This course is a continuation of BE410 by having student teams implement their design plan.  This will include development of a test plan, modifications to the design project as needed, and assessment of design performance relative to initial specifications.  This course culminates in the submission of the final design document.

BE 430 Biomedical Engineering Design III  1R-3L-2C  S  Pre: BE420
This course is a continuation of BE420 and introduces students to the skills necessary for professional practice in biomedical engineering including project management, review of critical design decisions, mentoring design teams, etc.  The biomedical engineering design sequence culminates in the formal oral presentation of the capstone design report.

BE 435 Biomedical Optics 4R-0L-4C W Pre: PH 113, MA 212, and SR/GR standing
  Optical techniques for biomedical applications and health care; laser fundamentals, laser interaction with tissues, laser diagnostics and therapy, laser surgery, endoscopy and applications; fiber optics; fiber optic biosensors; microscopes; optics- based clinical applications.  Same as OE 435.  Students taking BE435/OE435 may not receive credit for BE535/OE535.

BE 482 Bioengineering Statistics 4R-0L-4C Pre: MA 223 or MA 382 and consent of instructor (cross listed with MA 482)
Hypothesis testing and confidence intervals for two means, two proportions, and two variances. Introduction to analysis of variance to include one factor and two factors (with interaction) designs. Presentation of simple linear and multiple linear regression modeling; development of analysis of contingency table to include logistic regression. Presentation of Log odds ratio as well as several non-parametric techniques of hypothesis testing and construction of non-parametric confidence intervals and correlation coefficients. Review of fundamental prerequisite statistics will be included as necessary.

BE 491  Special Topics in Biomedical Engineering  XR-0L-XC  Arranged Pre: Consent of instructor
Covers upper-level, undergraduate material of mutual interest to student and instructor which cannot be acquired in any other listed undergraduate BE course.

BE492 Directed Study in Biomedical Engineering XR-XL-XC Arranged Pre: Consent of instructor
Covers biomedical engineering material of mutual interest to the student and instructor which cannot be experienced in any other listed BE course. A student may take between 1-4 credits in any given term.

BE 499 Thesis Research 0R-6L-2C F, W, S Pre: Junior or senior standing
Culmination of biomedical engineering thesis research in which a student writes and
submits the senior thesis, following departmentally established guidelines, and gives an
oral research presentation to at least three departmental faculty members, including the
student's advisor. BE499 may not be used as a biomedical engineering area elective.

BE 510 Biomedical Signal and Image Processing, 3R-3L-4C W Pre: BE201, JR, SR or Graduate standing or consent of instructor
Provides a comprehensive survey of signal and image processing tools for biomedical applications. Major biological signals (e.g., ECG), biomedical imaging techniques (e.g., MRI), their origin and importance, and the commonly used processing techniques with an emphasis on physiology and diagnostic applications will be discussed.

BE 511 Human Physiology A 3R-3L-4C F Pre: Junior, Senior, Graduate standing or consent of instructor  
An analysis of neural, muscular, endocrine, reproductive and digestive physiology from a quantitative, systems-based approach. Both recent and classical journal articles will be discussed in class.

BE 512 Human Physiology B 3R-3L-4C W Pre: Junior, Senior, Graduate standing or consent of instructor 
An analysis of cardiovascular, pulmonary, immune and renal physiology from a quantitative, systems-based approach. Both recent and classical journal articles will be discussed in class. (Note: BE511 is not a prerequisite for BE512).

BE 516 Introduction to MEMS: Fabrication and Applications 3R-3L-4C S Pre: JR or SR standing 
Properties of silicon wafers, wafer-level processes, surface and bulk micromachining, thin-film deposition, dry and wet etching, photolithography, process integration, simple actuators. Introduction to microfluidic systems. MEMS application: capacitive accelerometer, cantilever and pressure sensor. Students enrolled in BE516 must do project work on a topic selected by the instructor.

BE 525 Biomedical Fluid Mechanics 3R-3L-4C Pre: EM 301 or CHE 301 or ES202 or consent of instructor 
Includes cardiovascular physiology, Poiseuille flow, pulsatile flow in rigid tubes, pulsatile flow in large arteries, blood flow in the microcirculation, flow and pressure measurement, prosthetic heart valves, prosthetic arteries, dimensional analysis and modeling.

BE 531 Biomechanics II 3R-3L-4C Pre: BE331 or consent of instructor 
Covers statics, dynamics and deformable body mechanics of biological systems. Topics include joint anatomy, muscle physiology, biomechanics of distance running, physiological response to acceleration, mechanics of bone, joint biomechanics and selected topics from current literature. The course includes a lab covering the use of a motion analysis system and force platforms.

BE 534 Soft Tissue Mechanics  3R-3L-4C Pre: EM 203 or EM 204, and BE 331, or consent of instructor
This course provides an introduction to the various approaches used in modelling soft tissues, with particular attention paid to those of the musculoskeletal system (e.g. ligament, tendon, cartilage).  Particular emphasis will be placed on the theoretical and experimental consequences of the large deformation behavior of these tissues. This course will serve as a Biomechanics track elective.

BE 535/OE 535 Biomedical Optics 4R-0L-4C W Pre: PH 113, MA 212, and SR/GR standing 
Optical techniques for biomedical applications and health care; laser fundamentals, laser interaction with tissues, laser diagnostics and therapy, laser surgery, endoscopy and applications; fiber optics; fiber optic biosensors; microscopes; optics-based clinical applications.  For graduate credit, students must do additional project work on a topic selected by the instructor.  Students taking BE535/OE535 may not receive credit for BE435/OE435.

BE 539 Multiscale Biomechanics 3R-3L-4C Pre: EM 203 or EM 204, and BE 331, or consent of instructor
This course provides a comprehensive exploration/overview of the multiple approaches available for the analysis of multiscale media, beginning from classical approaches in composite theory and moving on to various structure-function and homogenization models.  Specific attention will be placed on the application of these ideas to heterogeneous and finite deformation biological tissues (e.g. bone, cartilage, ligament, vessels, etc.).    This course will serve as a Biomechanics track elective.

BE 541  Medical Imaging 4R-0L-4C Pre: JR/SR/GR standing and consent of instructor.
Engineering principles of major imaging techniques/modalities for biomedical applications and health care including computed tomography, ultrasound, and magnetic resonance imaging. Topics include general characteristics of medical images; physical principles and instrumentation of imaging modalities.  Clinical applications of these technologies are also discussed.

BE 543 Neuroprosthetics 3R-3L-4C Pre:BE310 and BE201
This course takes a detailed look at the state of the art in Neuroprosthetics design and applications.  Topics include electrode design, sensory prosthetics, functional electrical stimulation, deep brain stimulation and other contemporary research topics. 

BE 545 Orthopaedic Biomechanics 4R-0L-4C Pre: EM 203 or EM 204, and BE 331 or consent of instructor
This course covers current topics in orthopaedic biomechanics including the application of solid mechanics principles to musculoskeletal activities, orthopaedic implants, and fracture fixation devices. Topics include joint loading; composition and mechanical behavior of orthopaedic tissues; design/analysis of artificial joints and fracture fixation prostheses; osteoporosis and osteoarthritis; and finite element modeling.

BE 550 Research Methods in Biomechanics 3R-3L-4C W Pre: BE 331 or consent of instructor
Focuses on the wide range of research methods used in the field of biomechanics.  Current literature will be reviewed to analyze the advantages and disadvantages of various research methodologies.  Topics will vary based on student interests and background, but may include topics such as motion/force analysis, soft tissue and bone mechanics, joint biomechanics, analysis of joint replacements, and fracture fixation.  Laboratory activities will reinforce the lecture topics and students will have the opportunity to investigate a biomechanics research topic in their area of interest.

BE 555 Electrophysiology 3R-3L-4C Pre: Junior, Senior, Graduate standing or consent of instructor 
Introduces students to concepts of electrical activity in cells and organs of the body. Topics include: origin of membrane potential, membrane channels, synaptic signaling, recording techniques, gross electrical potentials (e.g. electrocardiogram, electroencephalogram, electromyogram, electroretinogram). Emphasis will be placed on how these signals are used to probe physiological function in the clinic and in the research laboratory.

BE 560: Tissue-Biomaterial Interactions 4R-0L-4C Pre: BE 361, or consent of instructor 
  Addresses interactions between living cells/tissues and implant biomaterials, stressing the importance of molecular- and cellular-level phenomena in initiating and propagating clinically relevant tissue- and systemic- level results.

BE 570 Introduction to Tissue Engineering 4R-0L-4C Pre: Junior, Senior, or Graduate standing or permission of instructor 
This course provides a broad overview of the latest developments in the field of tissue engineering. Normal structure and function of tissues and organs such as bone, cartilage, nerve, skin, and liver are discussed. Methods of engineering these tissues, or encouraging healing or regeneration that would not otherwise occur, is the focus of the course. The course takes the format of a graduate seminar, with students taking an active role in presenting material to the class and leading discussions.

BE 590 Thesis Research F,W,S 
Credits as assigned: however, not more than 12 credits will be applied toward the requirements of an M.S. degree.

BE 597 Selected Topics for Graduate Students Credits as assigned. Maximum 4 credits per term. F,W,S


The following courses are offered at the Terre Haute Center for Medical Education and may be taken for Rose-Hulman credit. To enroll in these courses RHIT students need permission from the Chairman of the Department of Applied Biology and Biomedical Engineering. BE 623 and BE 624 are typically offered in fall semester and BE 621 and BE 625 are typically offered in spring semester.

BE 621 Microbiology and Immunology (6 cr.)
Lectures, conferences and laboratories covering the immune response as a chemical and cellular Surveillance system; the consequences of activation of the immune system; and viruses, bacteria, fungi and protozoan and metazoan parasites as organisms and as agents of human disease.

BE 623 Gross Anatomy (8 cr.)
An intensive study of the gross structure of the human body accomplished through maximum student participation in the dissection of the human cadaver. Lectures are interpretive and correlative. Audiovisual supplementation is provided.

BE 624 Biochemistry (6 cr.)
The chemistry and reactions of constituents of living matter, including the carbohydrates, lipids, proteins, nucleic acids, vitamins, coenzymes and minerals; the chemistry and regulation of the reactions and processes of whole organisms; endocrinology; enzymology; nutrition; intermediary metabolism; and biochemical mechanisms in selected disease states.

BE 625 Physiology (8 cr.)
The course in human physiology covers, in lectures and laboratories, such topics as circulation, respiration, digestion, endocrinology, heat metabolism, renal physiology, muscle physiology, and neurophysiology.