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Mark Brandt

Professor of Chemistry

Dr. Mark Brandt specializes in organic and biochemistry. His research activities focus on the human estrogen receptor hormone binding domain (a key element of cancer research), as well as the control of carbohydrate metabolism. Students who work with Dr. Brandt in these research areas learn a variety of techniques used in both industrial and academic laboratories. Dr. Brandt is co-director of Rose-Hulman’s Interdisciplinary Research Collaborative, which offers students summer research opportunities, and he assisted in forming the new academic degree in biomathematics. In his spare time, he enjoys traveling and digital photography. Check out his personal web page

Teaching Interests

  • Biochemistry
  • Organic chemistry

Research Experiences

  • Estrogen receptor biochemistry
  • Interaction of small molecules with proteins
  • Computational biochemistry

Select Publications & Presentations

  • Brandt, M. E., Holder A., and Shibberu, Y., “Fundamentals of Protein Structure Alignment,” Algorithmic and Artificial Intelligence Methods for Protein Bioinformatics, Wiley Series in Bioinformatics, 2013
  • Shibberu, Y., and Brandt, M. E., “Contact Geometry of Estrogen Receptor Dynamics,” 20th Annual International Conference on Intelligent Systems for Molecular Biology, Long Beach, California, 2012
  • Shibberu, Y., Brandt, M. E., and Cooper, D., “Intrinsic Contact Geometry of Protein Dynamics,” International Conference on Bioinformatics Computational Biology 2010, 215-219, 2010
  • Gomez-Casati, D. F., Igarashi R. Y., Berger, C. N., Brandt, M. E., Iglesias, A. A., and Meyer, C. R., “Identification of Functionally Important Amino Terminal Arginines of Agrobacterium tumefaciens ADP-Glucose Pyrophosphorylase, Alanine-Scanning Mutagenesis,” Biochemistry 40: 10169-10178, 2001
  • Brandt, M. E. and Vickery, L. E., “Cooperativity and Dimerization of Recombinant Human Estrogen Receptor Hormone Binding Domain,” Journal of Biological Chemistry, 272: 4843-4849, 1997
  • Brandt, M. E. and Vickery, L. E., “Charge Pair Interactions Stabilizing Ferredoxin-Ferredoxin Reductase Complexes: Identification by Complementary Site-Specific Mutations,” Journal of Biological Chemistry, 268: 17126-17130, 1993

Awards & Honors

  • BS, College of William and Mary, 1982
  • MS, Vanderbilt University, 1986
  • PhD, University of Miami, 1989