COURSE DESCRIPTIONS
Applied Biology and Biomedical Engineering
Faculty - Ahmed, Anthony, Buckley, Dee, Ingram, Livesay, Rogge, Waite, Weiner
Affiliated Biomedical Engineering Faculty
- Bunch, Hoover, Hudson, Joenathan, Kirtley, McLean, Stamper, Tilstra, and Western.
APPLIED
BIOLOGY COURSES
AB101 Essential Biology
4R-OL-4C F,W,S
Pre: None
Surveys basic concepts
in the biological sciences and describes how new advances related to these
concepts affect contemporary society.
AB
110 Biology I-Cell Structure and Function
3R-3L-4C F,S
Pre: None
Introduces structures,
mechanisms, and laboratory techniques in cellular and molecular biology.
Discusses biomolecules, bioenergetics, biosynthesis, enzymatic function,
genetics, and cellular regulatory systems.
AB
120 Biology II - Comparative Anatomy & Physiology
3R-3L-4C W Pre: AB110
The structural and functional relationships between tissues and organ
systems are discussed using a comparative approach. The lecture is combined
with laboratory exercises and observations, which may require dissection of
biological specimens.
AB 130 Biology III - Evolution and
Diversity 3R-3L-4C S
Pre: AB110
Introduces fundamental principles, important applications, and field and
laboratory techniques in organismal biology. Discusses mechanisms of evolution,
the history of life on earth, biological diversity, and ecology.
AB 210 Mendelian and Molecular
Genetics 3R-3L-4C F Pre: AB 110 or instructor consent
A discussion of Mendelian genetics including the molecular mechanisms of
nuclear and cytoplasmic inheritance. Information flow and control of gene
expression are addressed at the molecular level. Basic genetic techniques are
covered in both lecture and laboratory.
AB 220 Prokaryotic Cell and
Molecular Biology 3R-3L-4C W Pre: AB 110 or instructor consent
Discusses the essential properties of eubacteria and archea. Bacterial
nutrition, growth, genetics and structural and metabolic diversity are discussed
in detail. The basics of virology are also addressed. Fundamental laboratory
methodologies are also covered.
AB 230 Eukaryotic Cell and
Molecular Biology 3R-3L-4C S Pre: AB 110 or instructor consent
Examines the structure and function of various eukaryotic cells.
Biomembranes, organelles, the cytoskeleton, energetics, protein sorting, signal
transduction and cell interactions are discussed in detail. Essential methods
in cell biology are addressed in both lectures and laboratories.
AB 264
Introduction to Environmental Science 4R-0L-4C W Pre: CHEM 111 or CHEM 201 or
instructor consent
This course will introduce students to the broad field of environmental
science by examining the biological, chemical, and physical processes that
regulate the earth’s ecosystems and the effect that anthropogenic activity has
in disrupting these components on the local and global scale. A final aspect of
the course will discuss sustainable human utilization of natural resources.
Cross-listed with CHEM 264.
AB 301, 302 Biology Colloquium
1R-0L-1C F, W Pre: Junior standing
A discussion of selected timely topics and preparation for senior research.
AB 310 Plant Structure & Function
3R-3L-4C S Pre: AB 130 or instructor consent
Surveys the structure, physiology, diversity, evolution, and ecological
importance of plants and related groups of organisms.
AB 320 Ecology
3R-3L-4C F Pre: AB 130 or instructor consent
Surveys adaptations of organisms, population dynamics, species interactions,
and the structure and function of natural communities and ecosystems.
AB 330 Evolutionary Biology
4R-0L-4C W Pre: AB 130 or instructor consent
Surveys three major themes of evolutionary biology: adaptation, diversity
of life, and the shared characteristics of life. Mechanisms of evolution,
speciation, phylogeny, and macroevolutionary processes are discussed.
AB340 Introduction to Biomedical Research: Clinical Methodology 1R–1L–1C Pre: AB120, 1R-1-1C and Jr/Sr standing or consent of instructor Designed to introduce applied biology/bioengineering students to the basics of biomedical research using the clinical methodology typical of patient sample analysis. Students will learn to relate testing procedures with specific diseases and to use data obtained from laboratory testing to understand more about specific patient health problems.
AB 401 Biology Colloquium
2R-0L-2C S Pre: Senior standing
Oral presentations and discussion of selected timely topics.
AB
410 Infection and Immunity 4R-0L-4C
Arranged Pre: AB 110 or consent of instructor
Discussion of various pathogens, how they cause disease, and how they elicit
the innate and adaptive immune responses employed to combat them. Cellular and
molecular mechanisms of immunity are addressed, as is the epidemiology of
various human diseases.
AB
411 Genetic Engineering
4R-0L-4C Arranged Pre: AB 210 or consent of instructor
Discusses the basics of molecular biology and the genetic and molecular
techniques used to engineer prokaryotic and eukaryotic cells, plants, and
animals for the production of useful traits or compounds. The application of
DNA technology to the diagnosis and treatment of disease is also addressed.
AB
421 Microbial Biotechnology
4R-0L-4C Arranged Pre: AB110 or consent of instructor
Discusses the fundamental biology of microprobes and the processes underlying
their use in the production of chemicals, therapeutics and foods. The basics of
microbial ecology and the environmental applications of microbial biotechnology
are also discussed.
AB 431 Genomics and Proteomics 4R-0L-4C
S Pre: AB210 or consent of instructor
Exploration of the
methodologies used to generate systems-level sets of genetic and protein data,
and the tools used to access and analyze the prodigious amounts of data emerging
from such projects. The application of these technologies to investigate
important biological questions and model complex biological systems is also
discussed.
AB
491 Special Topics in Applied Biology
XR-0L-XC Arranged Pre: Consent of
instructor
Covers upper level material of mutual interest to student and instructor which
cannot be acquired in any other listed AB course.
AB
492 Special Topics Applied Biology Laboratory
XR-XL-XC Arranged Pre: Consent of
instructor
Covers upper level biological laboratory experiments of mutual interest to the
student and instructor which cannot be experienced in any other listed AB
course.
AB
499 Senior Thesis Research 0R-12L-4C F, W, S Pre: Senior
standing
Laboratory research under the
direction of a faculty mentor. Culminates in an oral research presentation and
publication of a Senior Thesis.
BIOMEDICAL
ENGINEERING COURSES
BE100 Problem Solving in the Biological Sciences and Engineering 3R-3L-4C
Pre: None S
Introduces students to computational tools for solving problems in biology and
biomedical engineering. Topics covered include structured programming in
Matlab, data visualization and presentation, and introductions to bioinformatics
and WorkingModel.
BE 200 Introduction to Biomedical Engineering
4R-0L-4C Pre: BE100 or instructor consent
Survey of current topics in Biomedical Engineering with guest lecturers from
industry and academia. Project work with emphasis on the design process,
solutions of open-ended problems by student teams, and communication.
BE310: Analysis of
Physiological Systems I: 3R-3L-4C F Pre: AB120
An analysis of neural, muscular, endocrine, reproductive and digestive
physiology from a quantitative, systems-based approach.
BE320: Analysis of
Physiological Systems II: 3R-3L-4C
W Pre: BE310
An analysis of cardiovascular,
pulmonary, immune and renal physiology from a quantitative, systems-based
approach.
BE
325 Biomedical Fluid Mechanics 3R-3L-4C Pre: EM 301 or CH 301 or
ES202 or consent of instructor
Includes cardiovascular physiology, Poiseuille flow, pulsatile flow in rigid
tubes, pulsatile flow in large arteries, blood flow in the microcirculation,
flow and pressure measurement, prosthetic heart valves, prosthetic arteries,
dimensional analysis and modeling.
BE
330 Biomechanics 3R-3L-4C W Pre: ES201, EM120, and BE200 or consent of
instructor
Covers statics, dynamics and deformable body mechanics of biological
systems. Topics include biomechanics of distance running, biomechanics of
swimming, physiological response to acceleration, mechanics of bone, and joint
anatomy & biomechanics.
BE340
Biomedical Instrumentation 4R-0L-4C F Pre: BE200 or
consent of instructor
Topics include Circuit analysis,
frequency analysis, biomedical transducers, design of biomedical devices,
introduction to imaging techniques.
BE 350 Biocontrol
Systems 4R-0L-4C
S Pre: ES 205
Systems representation and analysis
in the frequency and time domain. Topics include Laplace transforms, modeling of electrical and mechanical systems, stability,
steady-state error analysis, root locus design, frequency response analysis, and
applications in physiology and medicine.
BE
390 Principles of Biomedical Engineering Design 1R-3L-2C
S Pre: BE200
In this course, junior BE majors are introduced to the engineering design
methodology as utilized in biomedical engineering. Students will learn
engineering design through completion of a team design project with realistic
constraints. This course serves as the entry point for the four-quarter
sequence in which students undertake and complete their capstone design project.
BE410 BE
Design I 3R-3L-4C
F
Pre: BE 390
This course begins the year-long capstone design project and continues to
investigate the process of design in biomedical engineering by having student
teams initiate the design process for a relevant problem in biomedical
engineering. This includes developing the design problem from a set of
client needs, establishing specifications, planning the project, scheduling,
efficient use of resources, examining ethics and safety in engineering design,
and working within explicit (or implicit) constraints such as social, fiscal,
manufacturing, etc. The course culminates with the presentation of the
preliminary proposal for the capstone design project in biomedical engineering.
BE420 BE
Design II 3R-3L-4C
W
Pre: BE 410
This course is a continuation of BE410 by having student teams implement their
design plan. This will include development of a test plan, modifications
to the design project as needed, and assessment of design performance relative
to initial specifications. This course culminates in the submission of the
final design document.
BE
422 Bioengineering Statistics 4R-0L-4C F Pre-. MA 205, MA 311 or MA 411
Estimation and hypothesis testing, regression analysis, analysis of variance,
measure of risk, rates and probability, cohort analysis, survival analysis,
clinical trials, quality control and susceptibility testing. Same as MA 422.
BE430 BE
Design III 1R-3L-2C S Pre: BE 420
This course is a continuation of BE420 and introduces students to the skills
necessary for professional practice in biomedical engineering including project
management, review of critical design decisions, mentoring design teams, etc.
The biomedical engineering design sequence culminates in the formal oral
presentation of the capstone design report.
BE
511 Human Physiology A 4R-0L-4C W (alternating years) Pre: Junior, Senior,
Graduate standing or consent of instructor
An analysis of neural, muscular,
endocrine, reproductive and digestive physiology from a quantitative,
systems-based approach. Both recent and classical journal articles will be
discussed in class.
BE 512 Human
Physiology B 4R-0L-4C W (alternating years) Pre: Junior, Senior, Graduate
standing or consent of instructor
An analysis of cardiovascular,
pulmonary, immune and renal physiology from a quantitative, systems-based
approach. Both recent and classical journal articles will be discussed in
class. (Note: BE511 is not a prerequisite for BE512).
BE516 Introduction
to MEMS: Fabrication and Applications 3R-3L-4C S Pre: JR or SR standing
Properties of silicon wafers,
wafer-level processes, surface and bulk micromachining, thin-film deposition,
dry and wet etching, photolithography, process integration, simple actuators.
Introduction to microfluidic systems. MEMS application: capacitive
accelerometer, cantilever and pressure sensor. Students enrolled in BE516 must
do project work on a topic selected by the instructor.
BE519 Advanced MEMS:
Modeling and Packaging 3R-3L-4C F Pre: PH410 or equivalent course
Design process, modeling: analytical
and numerical. Actuators; dynamics and thermal issues. Use of software for
layout and simulation. Characterization and reliability of MEMS devices.
Electrical interfacing and packaging of MEMS. Microsensors, microfluidic
systems, applications in engineering, biology, chemistry, and physics. Students
enrolled in BE519 must do project work on a topic selected by the instructor.
BE
525 Biomedical Fluid Mechanics 4R-0L-4C Pre: EM 301 or CH 301 or ES202 or
consent of instructor
Includes cardiovascular physiology,
Poiseuille flow, pulsatile flow in rigid tubes, pulsatile flow in large
arteries, blood flow in the microcirculation, flow and pressure measurement,
prosthetic heart valves, prosthetic arteries, dimensional analysis and modeling.
BE
530 Biomechanics 4R-0L-4C W Pre: ES201 or EM120 or consent of instructor
Covers statics, dynamics and
deformable body mechanics of biological systems. Topics include biomechanics of
distance running, physiological response to acceleration, mechanics of bone,
joint biomechanics and selected topics from current literature.
BE535/OE535
Biomedical Optics 4R-0L-4C Pre: PH 113, MA 202 or MA 213, and SR/GR
standing
Optical techniques for biomedical applications and health care; laser
fundamentals, laser interaction with tissues; laser diagnostics and therapy,
laser surgery, endoscopy and applications; fiber optics; fiber optic biosensors;
microscopes; optics-based clinical applications. For graduate credit,
students must do additional project work on a topic selected by the instructor.
BE540/PH540
Biothermodynamics 4R-0L-4C Pre: PH 113, MA 202 or MA 213, and JR/SR/GR standing
or consent of instructor
Heat transfer in biological tissue; determination of thermodynamic and
transport properties of tissue; clinical applications of heat transfer for
diagnosis and therapy. Calculation of the rate of heat production caused by
direct absorption of laser light, calculation of thermal damage, and calculation
of ablation.
BE 545 Orthopaedic Biomechanics
4R-0L-4C Pre: EM 203 and BE 330 or instructor consent
This course covers current topics in orthopaedic
biomechanics including the application of solid mechanics principles to
musculoskeletal activities, orthopaedic implants, and fracture fixation devices.
Other specific biomechanics topics include forces and moments acting on human
joints during normal activities; composition and mechanical behavior of
orthopaedic tissues (bone, cartilage, tendon, ligament, and muscle);
design/analysis of artificial joints and fracture fixation prostheses; the
biomechanical impact of implants on the musculoskeletal system; osteoporosis and
osteoarthritis; and the role of finite element modeling in orthopaedic
biomechanics.
BE
550 Biomedical Instrumentation 4R-0L-4C F Pre, Senior, Graduate standing or
consent of instructor
Topics include Circuit analysis,
frequency analysis, biomedical transducers, design of biomedical devices,
introduction to imaging techniques.
BE555
Electrophysiology 4R-0L-4C Pre: Junior, Senior,Graduate standing or consent
of instructor
Introduces students to concepts of
electrical activity in cells and organs of the body. Topics include: origin of
membrane potential, membrane channels, synaptic signaling, recording techniques,
gross electrical potentials (e.g. electrocardiogram, electroencephalogram,
electromyogram, electroretinogram). Emphasis will be placed on how these
signals are used to probe physiological function in the clinic and in the
research laboratory.
BE
560 Tissue-Biomaterial Interactions 4R-0L-4C Pre: BE360 or consent of instructor
Addresses interactions between living cells/tissues and implant biomaterials,
stressing the importance of molecular- and cellular-level phenomena in
initiating and propagating clinically relevant tissue- and systemic-level
results.
BE 561 Biomaterials--Prosthetic Devices 4R-0L-4C Pre: Junior, Senior class standing or consent of instructor Consecutively treats chemical and physical property of ceramics, carbons, and composites used as biomaterials, anatomy of the musculoskeletal system, bone and muscle physiology, review of the status of artificial hips, knees, shoulders, fingers, fixation devices and spinal implants. Extensive discussion on the problems of wear, corrosion, fretting and fatigue of prosthetic devices, review of the status of maxillofacial implants.
BE 562 Biomaterials
– Medical Devices, Surgical and Medical Instrumentation 4R-0L-4C S Pre:
Junior, Senior, Graduate standing or permission of instructor
Review of the status of dental,
maxillofacial and percutaneous implants, materials for surgical instruments,
laparoscopy surgery and endoscopy surgery. Review of ASTM and ISO Standards for
Biomaterials. Review of the process for the development of new medical devices
with particular emphasis on preparing documents for FDA approval. Introduction
to genetic engineering and tissue engineering.
BE
570 Introduction to Tissue Engineering 4R-0L-4C S Pre: Junior, Senior, or
Graduate standing or permission of instructor
This course provides a broad
overview of the latest developments in the field of tissue engineering. Normal
structure and function of tissues and organs such as bone, cartilage, nerve,
skin, and liver are discussed. Methods of engineering these tissues, or
encouraging healing or regeneration that would not otherwise occur, is the focus
of the course. The course takes the format of a graduate seminar, with students
taking an active role in presenting material to the class and leading
discussions.
BE
590 Thesis Research FWS
Credits as assigned: however, not more than 12 credits will be applied toward
the requirements of an M.S. degree.
BE 597 Selected
Topics for Graduate Students Credits as assigned. Maximum 4 credits per term.
F,W,S
The following courses are offered at the Terre Haute Center for Medical Education and may be taken for Rose-Hulman credit. To enroll in these courses RHIT students need permission from the Chairman of the Department of Applied Biology and Biomedical Engineering. BE 623 and BE 624 are typically offered in fall semester and BE 621 and BE 625 are typically offered in spring semester.
COURSES OFFERED AT THE TERRE HAUTE CENTER FOR MEDICAL EDUCATION
BE
621 Medical Microbiology (6 cr.)
Lectures, conferences and
laboratories covering the immune response as a chemical and cellular
surveillance system; the consequences of activation of the immune system; and
viruses, bacteria, fungi and protozoan and metazoan parasites as organisms and
as agents of human disease.
BE
623 Gross Anatomy (8 cr.)
An intensive study of the gross
structure of the human body accomplished through maximum student participation
in the dissection of the human cadaver. Lectures are interpretive and
correlative. Audiovisual supplementation is provided.
BE
624 Biochemistry (6 cr.)
The chemistry and reactions of
constituents of living matter, including the carbohydrates, lipids, proteins,
nucleic acids, vitamins, coenzymes and minerals; the chemistry and regulation
of the reactions and processes of whole organisms; endocrinology; enzymology;
nutrition; intermediary metabolism; and biochemical mechanisms in selected
disease states.
BE
625 Physiology (8 cr.)
The course in human physiology
covers, in lectures and laboratories, such topics as circulation, respiration,
digestion, endocrinology, heat metabolism, renal physiology, muscle physiology,
and neurophysiology.
This page last updated on April 18, 2003