Applied Biology and Biomedical Engineering Faculty — Ahmed, Anthony, Buchmann, Buckley, Coppinger, Dee, Ingram, Livesay, Rogge, Waite, Weiner

Applied Biology

AB 101 Essential Biology 4R-OL-4C F,W,S Pre: None
  Surveys basic concepts in the biological sciences and describes how new advances related to these concepts affect contemporary society.

AB 110 Biology I – Cell Structure and Function 3R-3L-4C F,S Pre: None
  Introduces structures, mechanisms, and laboratory techniques in cellular and molecular biology. Discusses biomolecules, bioenergetics, biosynthesis, enzymatic function, genetics, and cellular regulatory systems.

AB 120 Biology II – Comparative Anatomy & Physiology 3R-3L-4C W Pre: AB 110 or instructor consent
  The structural and functional relationships between tissues and organ systems are discussed using a comparative approach. The lecture is combined with laboratory exercises and observations, which may require dissection of biological specimens.

AB 130 Biology III – Evolution and Diversity 3R-3L-4C S Pre: AB 120 or instructor consent
  Introduces fundamental principles, important applications, and field and laboratory techniques in organismal biology. Discusses mechanisms of evolution, the history of life on earth, biological diversity, and ecology.

AB 210 Mendelian and Molecular Genetics 3R-3L-4C F Pre: AB 110 or instructor consent
  A discussion of Mendelian genetics including the molecular mechanisms of nuclear and cytoplasmic inheritance. Information flow and control of gene expression are addressed at the molecular level. Basic genetic techniques are covered in both lecture and laboratory.

AB 220 Prokaryotic Cell and Molecular Biology 3R-3L-4C W Pre: AB 110 or instructor consent
  Discusses the essential properties of eubacteria and archea. Bacterial nutrition, growth, genetics and structural and metabolic diversity are discussed in detail. The basics of virology are also addressed. Fundamental laboratory methodologies are also covered.

AB 230 Eukaryotic Cell and Molecular Biology 3R-3L-4C S Pre: AB 110 or instructor consent
  Examines the structure and function of various eukaryotic cells. Biomembranes, organelles, the cytoskeleton, energetics, protein sorting, signal transduction and cell interactions are discussed in detail. Essential methods in cell biology are addressed in both lectures and laboratories.

AB 264 Introduction to Environmental Science 4R-0L-4C W Pre: CHEM 111 or CHEM 201 or consent of instructor
  This course will introduce students to the broad field of environmental science by examining the biological, chemical, and physical processes that regulate the earth’s ecosystems and the effect that anthropogenic activity has in disrupting these components on the local and global scale. A final aspect of the course will discuss sustainable human utilization of natural resources. Cross-listed with CHEM 264.

AB 301, 302 Biology Colloquium 1R-0L-1C F, W Pre: Junior standing
  A discussion of selected timely topics and preparation for senior research.

AB 310 Plant Structure & Function 3R-3L-4C S Pre: AB 130 or instructor consent
  Surveys the structure, physiology, diversity, evolution, and ecological importance of plants and related groups of organisms.

AB 320 Ecology 3R-3L-4C F Pre: AB 130 or instructor consent
  Surveys adaptations of organisms, population dynamics, species interactions, and the structure and function of natural communities and ecosystems.

AB 330 Evolutionary Biology 4R-0L-4C W Pre: AB 130 or instructor consent
  Surveys three major themes of evolutionary biology: adaptation, diversity of life, and the shared characteristics of life. Mechanisms of evolution, speciation, phylogeny, and macroevolutionary processes are discussed.

AB 340 Introduction to Biomedical Research: Clinical Methodology 1R-1L-1C Pre: AB120, and Jr/Sr standing or consent of instructor
  Designed to introduce applied biology/bioengineering students to the basics of biomedical research using the clinical methodology typical of patient sample analysis. Students will learn to relate testing procedures with specific diseases and to use data obtained from laboratory testing to understand more about specific patient health problems.

AB 401 Biology Colloquium 2R-0L-2C S Pre: Senior standing
  Oral presentations and discussion of selected timely topics.

AB 410 Infection and Immunity 4R-0L-4C Arranged Pre: AB 110 or consent of instructor
  Discussion of various pathogens, how they cause disease, and how they elicit the innate and adaptive immune responses employed to combat them. Cellular and molecular mechanisms of immunity are addressed, as is the epidemiology of various human diseases.

AB 411 Genetic Engineering 4R-0L-4C Arranged Pre: AB 210 or consent of instructor
  Discusses the basics of molecular biology and the genetic and molecular techniques used to engineer prokaryotic and eukaryotic cells, plants, and animals for the production of useful traits or compounds. The application of DNA technology to the diagnosis and treatment of disease is also addressed.

AB 421 Microbial Biotechnology 4R-0L-4C Arranged Pre: AB110 or consent of instructor
  Discusses the fundamental biology of microprobes and the processes underlying their use in the production of chemicals, therapeutics and foods. The basics of microbial ecology and the environmental applications of microbial biotechnology are also discussed.

AB 431 Genomics and Proteomics 4R-0L-4C S Pre: AB210 or consent of instructor
  Exploration of the methodologies used to generate systems-level sets of genetic and protein data, and the tools used to access and analyze the prodigious amounts of data emerging from such projects. The application of these technologies to investigate biological questions and model complex biological systems is also discussed.

AB 491 Special Topics in Applied Biology XR-0L-XC Arranged Pre: Consent of instructor
  Covers upper level material of mutual interest to student and instructor which cannot be acquired in any other listed AB course.

AB 492 Special Topics Applied Biology Laboratory XR-XL-XC Arranged Pre: Consent of instructor
  Covers upper level biological laboratory experiments of mutual interest to the student and instructor which cannot be experienced in any other listed AB course.

AB 499 Senior Thesis Research 0R-12L-4C F, W, S Pre: Senior standing
  Laboratory research under the direction of a faculty mentor. Culminates in an oral research presentation and publication of a Senior Thesis.

Biomedical Engineering

BE 100: Problem Solving in the Biological Sciences and Engineering 
3R-3L-4C   Pre: None   S
  Introduces students to computational tools for solving problems in biology and biomedical engineering.  Topics covered include structured programming in Matlab, data visualization and presentation, and introductions to bioinformatics and WorkingModel.

BE 200 Introduction to Biomedical Engineering 4R-0L-4C  Pre:  BE 100 or consent of instructor
  Survey of current topics in Biomedical Engineering with guest lecturers from industry and academia.   Project work with emphasis on the design process, solutions of open-ended problems by student teams, and communication.

BE 310 Analysis of Physiological Systems  I:   3R-3L-4C   F   Pre: AB120
  An analysis of neural, muscular, endocrine, reproductive and digestive physiology from a quantitative, systems-based approach.

BE 320 Analysis of Physiological Systems II:  3R-3L-4C   W     Pre: BE310
  An analysis of cardiovascular, pulmonary, immune and renal physiology from a quantitative, systems-based approach.

BE 325 Biomedical Fluid Mechanics 3R-3L-4C   Pre: EM 301 or CHE 301 or ES 202 or consent of instructor
  Includes cardiovascular physiology, Poiseuille flow, pulsatile flow in rigid tubes, pulsatile flow in large arteries, blood flow in the microcirculation, flow and pressure measurement, prosthetic heart valves, prosthetic arteries, dimensional analysis and modeling.

BE 330 Biomechanics 3R-3L-4C  W  Pre: ES201, EM120, and BE 200 or consent of instructor
  Covers statics, dynamics and deformable body mechanics of biological systems. Topics include biomechanics of distance running, biomechanics of swimming, physiological response to acceleration, mechanics of bone, and joint anatomy & biomechanics.

BE 340 Biomedical Instrumentation 4R-0L-4C F Pre: BE 200 or consent of instructor
  Topics include Circuit analysis, frequency analysis, biomedical transducers, design of biomedical devices, introduction to imaging techniques.

BE 350 Biocontrol Systems 4R-0L-4C W Pre: ES 205
  Systems representation and analysis in the frequency and time domain.  Topics include Laplace transforms, modeling of electrical and mechanical systems, stability, steady-state error analysis, root locus design, frequency response analysis, and applications in physiology and medicine.

BE 360 Biomaterials 4R-0L-4C W Pre: BE 200 or consent of instructor
  Structure-property relationships for metallic, polymeric, and ceramic biomaterials.  Study of the interactions of these materials with the body and factors affecting the selection and design of materials for medical implants and devices.

BE 390 – Principles of Biomedical Engineering Design  1R-3L-2C  S 
Pre: BE 200
  In this course, junior BE majors are introduced to the engineering design methodology as utilized in biomedical engineering.  Students will learn engineering design through completion of a team design project with realistic constraints. This course serves as the entry point for the four-quarter sequence in which students undertake and complete their capstone design project.

BE 410 – Biomedical Engineering Design I  3R-3L-4C  F  Pre: BE390
  This course begins the year-long capstone design project and continues to investigate the process of design in biomedical engineering by having student teams initiate the design process for a relevant problem in biomedical engineering. This includes developing the design problem from a set of client needs, establishing specifications, planning the project, scheduling, efficient use of resources, examining ethics and safety in engineering design, and working within explicit (or implicit) constraints such as social, fiscal, manufacturing, etc.  The course culminates with the presentation of the preliminary proposal for the capstone design project in biomedical engineering.

BE 420 – Biomedical Engineering Design II  2R-6L-4C  W  Pre: BE410
  This course is a continuation of BE410 by having student teams implement their design plan.  This will include development of a test plan, modifications to the design project as needed, and assessment of design performance relative to initial specifications.  This course culminates in the submission of the final design document.

BE 430 – Biomedical Engineering Design III  1R-3L-2C  S  Pre: BE420
  This course is a continuation of BE420 and introduces students to the skills necessary for professional practice in biomedical engineering including project management, review of critical design decisions, mentoring design teams, etc.  The biomedical engineering design sequence culminates in the formal oral presentation of the capstone design report.

BE 482 Bioengineering Statistics 4R-0L-4C Pre: MA 223 or MA 382 and consent of instructor (cross listed with MA 482)
  Hypothesis testing and confidence intervals for two means, two proportions, and two variances. Introduction to analysis of variance to include one factor and two factors (with interaction) designs. Presentation of simple linear and multiple linear regression modeling; development of analysis of contingency table to include logistic regression. Presentation of Log odds ratio as well as several non-parametric techniques of hypothesis testing and construction of non-parametric confidence intervals and correlation coefficients. Review of fundamental prerequisite statistics will be included as necessary.

BE 511 Human Physiology A 4R-0L-4C W (alternating years) Pre: Junior, Senior, Graduate standing or consent of instructor
  An analysis of neural, muscular, endocrine, reproductive and digestive physiology from a quantitative, systems-based approach. Both recent and classical journal articles will be discussed in class.

BE 512 Human Physiology B 4R-0L-4C W (alternating years) Pre: Junior, Senior, Graduate standing or consent of instructor
  An analysis of cardiovascular, pulmonary, immune and renal physiology from a quantitative, systems-based approach. Both recent and classical journal articles will be discussed in class. (Note: BE511 is not a prerequisite for BE512).

BE 516 Introduction to MEMS: Fabrication and Applications 3R-3L-4C S Pre: JR or SR standing
  Properties of silicon wafers, wafer-level processes, surface and bulk micromachining, thin-film deposition, dry and wet etching, photolithography, process integration, simple actuators. Introduction to microfluidic systems. MEMS application: capacitive accelerometer, cantilever and pressure sensor. Students enrolled in BE516 must do project work on a topic selected by the instructor.

BE 519 Advanced MEMS: Modeling and Packaging 3R-3L-4C F Pre: PH410 or equivalent course
  Design process, modeling: analytical and numerical. Actuators; dynamics and thermal issues. Use of software for layout and simulation. Characterization and reliability of MEMS devices. Electrical interfacing and packaging of MEMS. Microsensors, microfluidic systems, applications in engineering, biology, chemistry, and physics. Students enrolled in BE519 must do project work on a topic selected by the instructor.

BE 525 Biomedical Fluid Mechanics 4R-0L-4C Pre: EM 301 or CHE 301 or ES202 or consent of instructor
  Includes cardiovascular physiology, Poiseuille flow, pulsatile flow in rigid tubes, pulsatile flow in large arteries, blood flow in the microcirculation, flow and pressure measurement, prosthetic heart valves, prosthetic arteries, dimensional analysis and modeling.

BE 530 Biomechanics 4R-0L-4C W Pre: ES201 or EM120 or consent of instructor
  Covers statics, dynamics and deformable body mechanics of biological systems. Topics include biomechanics of distance running, physiological response to acceleration, mechanics of bone, joint biomechanics and selected topics from current literature.

BE 535/OE 535 Biomedical Optics 4R-0L-4C W Pre: PH 113, MA 222, and SR/GR standing
   Optical techniques for biomedical applications and health care; laser fundamentals, laser interaction with tissues, laser diagnostics and therapy, laser surgery, endoscopy and applications; fiber optics; fiber optic biosensors; microscopes; optics-based clinical applications.  For graduate credit, students must do additional project work on a topic selected by the instructor.

BE 540/PH 540 Biothermodynamics 4R-0L-4C Pre: PH 113, MA 222, and JR/SR/GR standing or consent of instructor
  Heat transfer in biological tissue; determination of thermodynamic and transport properties of tissue; clinical applications of heat transfer for diagnosis and therapy. Calculation of the rate of heat production caused by direct absorption of laser light, calculation of thermal damage, and calculation of ablation.

BE 545 Orthopaedic Biomechanics 4R-0L-4C Pre: EM 203 and BE 330 or consent of instructor
  This course covers current topics in orthopaedic biomechanics including the application of solid mechanics principles to musculoskeletal activities, orthopaedic implants, and fracture fixation devices. Other specific biomechanics topics include forces and moments acting on human joints during normal activities; composition and mechanical behavior of orthopaedic tissues (bone, cartilage, tendon, ligament, and muscle); design/analysis of artificial joints and fracture fixation prostheses; the biomechanical impact of implants on the musculoskeletal system; osteoporosis and osteoarthritis; and the role of finite element modeling in orthopaedic biomechanics.

BE 555 Electrophysiology 4R-0L-4C Pre: Junior, Senior, Graduate standing or consent of instructor
  Introduces students to concepts of electrical activity in cells and organs of the body. Topics include: origin of membrane potential, membrane channels, synaptic signaling, recording techniques, gross electrical potentials (e.g. electrocardiogram, electroencephalogram, electromyogram, electroretinogram). Emphasis will be placed on how these signals are used to probe physiological function in the clinic and in the research laboratory.

BE 560: Tissue-Biomaterial Interactions F 4R-0L-4C Pre: BE 360, or consent of instructor
  Addresses interactions between living cells/tissues and implant biomaterials, stressing the importance of molecular- and cellular-level phenomena in initiating and propagating clinically relevant tissue- and systemic- level results.

BE 561 Biomaterials—Prosthetic Devices 4R-0L-4C Pre: Junior, Senior class standing or consent of instructor
  Consecutively treats chemical and physical property of ceramics, carbons, and composites used as bio-materials, anatomy of the musculoskeletal system, bone and muscle physiology, review of the status of artificial hips, knees, shoulders, fingers, fixation devices and spinal implants. Extensive discussion on the problems of wear, corrosion, fretting and fatigue of prosthetic devices, review of the status of maxillofacial implants.

BE 562 Biomaterials – Medical Devices, Surgical and Medical Instrumentation 4R-0L-4C S Pre: Junior, Senior, Graduate standing or consent of instructor
  Review of the status of dental, maxillofacial and percutaneous implants, materials for surgical instruments, laparoscopy surgery and endoscopy surgery. Review of ASTM and ISO Standards for Biomaterials. Review of the process for the development of new medical devices with particular emphasis on preparing documents for FDA approval. Introduction to genetic engineering and tissue engineering.

BE 570 Introduction to Tissue Engineering 4R-0L-4C S Pre: Junior, Senior, or Graduate standing or permission of instructor
  This course provides a broad overview of the latest developments in the field of tissue engineering. Normal structure and function of tissues and organs such as bone, cartilage, nerve, skin, and liver are discussed. Methods of engineering these tissues, or encouraging healing or regeneration that would not otherwise occur, is the focus of the course. The course takes the format of a graduate seminar, with students taking an active role in presenting material to the class and leading discussions.

BE 590 Thesis Research F,W,S
  Credits as assigned: however, not more than 12 credits will be applied toward the requirements of an M.S. degree.

BE 597 Selected Topics for Graduate Students Credits as assigned. Maximum 4 credits per term. F,W,S

 

The following courses are offered at the Terre Haute Center for Medical Education and may be taken for Rose-Hulman credit. To enroll in these courses RHIT students need permission from the Chairman of the Department of Applied Biology and Biomedical Engineering. BE 623 and BE 624 are typically offered in fall semester and BE 621 and BE 625 are typically offered in spring semester.

BE 621 Microbiology and Immunology (6 cr.)
  Lectures, conferences and laboratories covering the immune response as a chemical and cellular Surveillance system; the consequences of activation of the immune system; and viruses, bacteria, fungi and protozoan and metazoan parasites as organisms and as agents of human disease.

BE 623 Gross Anatomy (8 cr.)
   An intensive study of the gross structure of the human body accomplished through maximum student participation in the dissection of the human cadaver. Lectures are interpretive and correlative. Audiovisual supplementation is provided.

BE 624 Biochemistry (6 cr.)
  The chemistry and reactions of constituents of living matter, including the carbohydrates, lipids, proteins, nucleic acids, vitamins, coenzymes and minerals; the chemistry and regulation of the reactions and processes of whole organisms; endocrinology; enzymology; nutrition; intermediary metabolism; and biochemical mechanisms in selected disease states.

BE 625 Physiology (8 cr.)
  The course in human physiology covers, in lectures and laboratories, such topics as circulation, respiration, digestion, endocrinology, heat metabolism, renal physiology, muscle physiology, and neurophysiology.